Department of Epidemiology and Health Statistics, The School of Public Health of Qingdao University, No. 308 Ningxia Road, Qingdao 266071, China.
Nutrients. 2022 Aug 26;14(17):3516. doi: 10.3390/nu14173516.
The evidence on the relationship of pyridoxal 5'-phosphate (PLP) with sleep-related problems is limited and controversial. Notably, there is a lack of studies on the general population and studies of the dose-response relationship. Therefore, we conducted a cross-sectional study to examine the associations between serum PLP concentration and sleep-related problems (sleep quality and sleep duration) in adults, using the data of the National Health and Nutrition Examination Survey 2005-2010. High-performance liquid chromatography (HPLC) was used to test PLP in blood samples. Sleep quality and sleep duration were based on self-reported data, with sleep quality categorized as sleep disorder, trouble falling asleep, waking up during the night, and daytime sleepiness. The primary analyses utilized logistic regression models and restricted cubic spline. Compared with the first quartile (Q1), the odds ratios (ORs) and 95% confidence intervals (CIs) of daytime sleepiness for the Q2 and Q3 of serum PLP concentrations were 0.76 (0.59-0.99) and 0.78 (0.62-0.98), respectively. The relationship was only significant for males. Furthermore, a non-linear dose-response relationship was observed between serum PLP concentration and the risk of daytime sleepiness. Compared with the normal sleep duration group, serum PLP concentrations were negatively associated with the risks of very short, short, and long sleep duration, with relative risk ratios (RRRs) of 0.58 (0.43-0.81) (Q4), 0.71 (0.61-0.83) (Q4) and 0.62 (0.34-0.94) (Q3), respectively. The average serum PLP concentrations were higher in people with normal sleep duration, suggesting a non-linear dose-response relationship. Our study indicated that serum PLP concentrations were negatively associated with daytime sleepiness, and this association may only exist in males. Moreover, it was also inversely related to abnormal sleep duration (very short, short, long) compared to normal sleep duration.
血清吡哆醛 5'-磷酸（PLP）与睡眠相关问题的关系的证据有限且存在争议。值得注意的是，缺乏对普通人群的研究以及剂量反应关系的研究。因此，我们使用 2005-2010 年国家健康和营养调查的数据进行了一项横断面研究，以检验成年人血清 PLP 浓度与睡眠相关问题（睡眠质量和睡眠时间）之间的关系。高效液相色谱法（HPLC）用于检测血液样本中的 PLP。睡眠质量和睡眠时间基于自我报告的数据，睡眠质量分为睡眠障碍、入睡困难、夜间醒来和白天嗜睡。主要分析采用逻辑回归模型和限制立方样条。与第一四分位数（Q1）相比，血清 PLP 浓度 Q2 和 Q3 的日间嗜睡的优势比（OR）和 95%置信区间（CI）分别为 0.76（0.59-0.99）和 0.78（0.62-0.98）。这种关系仅在男性中具有显著性。此外，还观察到血清 PLP 浓度与日间嗜睡风险之间存在非线性剂量反应关系。与正常睡眠时间组相比，血清 PLP 浓度与极短、短和长睡眠时间的风险呈负相关，相对风险比（RRR）分别为 0.58（0.43-0.81）（Q4）、0.71（0.61-0.83）（Q4）和 0.62（0.34-0.94）（Q3）。正常睡眠时间组的平均血清 PLP 浓度较高，提示存在非线性剂量反应关系。我们的研究表明，血清 PLP 浓度与日间嗜睡呈负相关，这种关联可能仅存在于男性中。此外，与正常睡眠时间相比，它还与异常睡眠时间（极短、短、长）呈负相关。
