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原发性肝肉瘤样癌:一例报告及临床特征与预后因素回顾性分析的见解

Primary hepatic carcinosarcoma: a case report with insights from retrospective analysis of clinical characteristics and prognostic factors.

作者信息

Zhao Zonglei, Wang Tao, Sun Zhexuan, Cao Xuefeng, Zhang Xingyuan

机构信息

Department of Hepatobiliary Surgery, Binzhou Medical University Hospital, Binzhou, China.

出版信息

Front Med (Lausanne). 2025 Jan 10;11:1470419. doi: 10.3389/fmed.2024.1470419. eCollection 2024.

Abstract

Primary hepatic carcinosarcoma (HCS) is an extremely rare malignant tumor with carcinomatous and sarcomatous elements. Few reported cases of HCS exist, especially with sufficient records to describe imaging and pathological features, making the diagnosis, treatment, and prognosis of HCS a significant challenge for physicians. Here, we report a case of HCS with spontaneous rupture as the initial symptom in a 77-year-old elderly male who was admitted with right upper abdominal pain for 8 days. The computed tomography enhancement scan revealed one intrahepatic enhancement with mixed density and a massive, enhanced shadow located mainly outside the liver. We performed a hepatectomy of segment 4 through a laparotomy. The postoperative pathology results demonstrated HCS. The patient recovered smoothly and was discharged after surgery. However, the patient experienced a recurrence and died 5 months after surgery. This case underscores the importance of identifying high-risk populations and personalized treatment strategies in HCS cases.

摘要

原发性肝肉瘤样癌(HCS)是一种极其罕见的同时具有癌性和肉瘤性成分的恶性肿瘤。关于HCS的报道病例很少,尤其是缺乏足够记录来描述其影像学和病理特征的情况,这使得HCS的诊断、治疗和预后成为医生面临的重大挑战。在此,我们报告一例以自发性破裂为首发症状的HCS病例,患者为一名77岁老年男性,因右上腹疼痛8天入院。计算机断层扫描增强扫描显示肝内一处混合密度增强影以及一个主要位于肝外的巨大增强阴影。我们通过剖腹手术对肝4段进行了肝切除术。术后病理结果证实为HCS。患者术后恢复顺利,术后出院。然而,患者术后5个月复发并死亡。该病例强调了在HCS病例中识别高危人群和制定个性化治疗策略的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a3/11757265/f812c7c64054/fmed-11-1470419-g001.jpg

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