Huamán-Mendoza Aldrin André, Pantigozo-Morán Fabiola Lucía, da Silva José Carlos, Chuquimez-Ventura Casimira Valeria, Holzhausen Marinella
Department of Stomatology, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, São Paulo, SP, Brazil.
J Periodontol. 2025 Jan 27. doi: 10.1002/JPER.24-0473.
The host immune response plays a major role in the pathogenesis of periodontitis. A bibliometric study can be crucial to understanding the different processes involved in this area; however, to our knowledge, it has not been published until now. Therefore, a bibliometric analysis was conducted to assess research hotspots and global trends in scientific articles about the immune response in periodontitis published between 1952 and 2023.
The search strategy was defined using keywords and Boolean operators. The Web of Science Core Collection database was used. In addition, the bibliometric analysis was performed using four tools: Python 3.12, VOSviewer 1.6.19, R-Bibliometrix, and CiteSpace.
A total of 7696 articles were included, comprising 6691 regular articles and 1005 review articles. Data analysis revealed an increasing trend in the number of publications over the years in this field, with the most cited article written by Preshaw et al. (2012). Leading countries in article production include the United States, China, Japan, and Brazil. Regarding institutions, the University of Helsinki had the highest number of publications (N = 339), with one of its researchers being the author with the most publications (Dr. Sorsa, N = 143, H-index = 52). Concerning journals, the Journal of Periodontology was the most influential journal. Finally, recent trending topics in research were related to the influence of inflammation on dysbiosis, immune biomarkers, immunomodulation, and the impact of aging on immunocompetence.
This bibliometric study demonstrated a growing interest and the emergence of new trends in research on host immune response in periodontitis.
宿主免疫反应在牙周炎发病机制中起主要作用。文献计量学研究对于理解该领域涉及的不同过程至关重要；然而，据我们所知，迄今为止尚未发表过相关研究。因此，进行了一项文献计量分析，以评估1952年至2023年发表的关于牙周炎免疫反应的科学文章的研究热点和全球趋势。
使用关键词和布尔运算符定义检索策略。使用Web of Science核心合集数据库。此外，使用四种工具进行文献计量分析：Python 3.12、VOSviewer 1.6.19、R-Bibliometrix和CiteSpace。
共纳入7696篇文章，其中包括6691篇常规文章和1005篇综述文章。数据分析显示，该领域多年来的出版物数量呈上升趋势，被引用次数最多的文章由普雷肖等人于2012年撰写。文章产出的主要国家包括美国、中国、日本和巴西。在机构方面，赫尔辛基大学的出版物数量最多（N = 339），其一名研究人员是发表文章最多的作者（索尔萨博士，N = 143，H指数 = 52）。在期刊方面，《牙周病学杂志》是最具影响力的期刊。最后，最近的研究热点话题与炎症对生态失调的影响、免疫生物标志物、免疫调节以及衰老对免疫能力的影响有关。
这项文献计量学研究表明，人们对牙周炎宿主免疫反应研究的兴趣日益浓厚，新趋势不断涌现。
