Ajam-Hosseini Mobarakeh, Babashah Sadegh
Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, P.O. Box: 14115-154, Tehran, Iran.
Mol Cell Biochem. 2025 Jan 27. doi: 10.1007/s11010-024-05169-9.
Ferroptosis is a novel, iron-dependent form of non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species (ROS) and mitochondrial shrinkage. It is closely associated with the onset and progression of various diseases, especially cancer, at all stages, making it a key focus of research for developing therapeutic strategies. Numerous studies have explored the role of microRNAs (miRNAs) in regulating ferroptosis by modulating the expression of critical genes involved in iron metabolism and lipid peroxidation. Due to their diversity, unique properties, and dynamic expression patterns in diseases, exosomal miRNAs are emerging as promising biomarkers. Exosomes act as biological messengers, delivering miRNAs to target cells through specific internalization, thus influencing the ferroptosis response in recipient cells. This review summarizes the roles of miRNAs, with particular focus on exosomal miRNAs, in ferroptosis and their implications for cancer pathology. By examining the molecular mechanisms of miRNAs, we aim to provide valuable insights into potential therapeutic approaches.
铁死亡是一种新型的、铁依赖性的非凋亡性细胞死亡形式，其特征是脂质活性氧（ROS）积累和线粒体萎缩。它与各种疾病，尤其是癌症在各个阶段的发生和发展密切相关，使其成为开发治疗策略研究的关键焦点。众多研究探讨了微小RNA（miRNA）通过调节参与铁代谢和脂质过氧化的关键基因的表达来调控铁死亡的作用。由于外泌体miRNA在疾病中的多样性、独特性质和动态表达模式，它们正成为有前景的生物标志物。外泌体作为生物信使，通过特定的内化作用将miRNA传递给靶细胞，从而影响受体细胞中的铁死亡反应。本综述总结了miRNA，特别是外泌体miRNA在铁死亡中的作用及其对癌症病理学的影响。通过研究miRNA的分子机制，我们旨在为潜在的治疗方法提供有价值的见解。
