Kaupper Christin, Blaauwendraad Sophia, Gaillard Romy, Koletzko Berthold V, Jaddoe Vincent
The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands,
Department of Pediatrics, Sophia Children's Hospital, Erasmus University Medical Center, Rotterdam, The Netherlands,
Ann Nutr Metab. 2025;81(3):171-179. doi: 10.1159/000543697. Epub 2025 Jan 27.
Adverse exposures in utero might cause adaptations of cardiovascular and metabolic organ development, predisposing individuals to an adverse cardio-metabolic risk profile from childhood onwards. We hypothesized that adaptations in metabolic pathways underlie these associations and examined associations of metabolite profiles at birth with childhood cardio-metabolic risk factors.
The study included 763 mother-child pairs participating in an ongoing population-based prospective cohort study with an overall low disease risk. Cord blood serum concentrations of amino acids (AAs), nonesterified fatty acids, phospholipids and carnitines (Carn) were obtained using a liquid chromatography coupled with tandem mass-spectrometry. We measured android/gynoid fat mass ratio, blood pressure, insulin, and lipid concentrations at the children's age of 5.9 (0.3) and 9.8 (0.9) years.
We did not observe associations of cord blood metabolites with systolic or diastolic blood pressure, insulin, triglycerides, and android/gynoid fat mass ratio at both ages and cardio-metabolic risk clustering at age 10 years. Five short- and medium-chain Carn.a metabolites were positively associated with cardio-metabolic risk clustering at age 6 but did not survive more stringent confounder adjustment.
No consistent associations between cord blood metabolites and cardiovascular risk factors at school age were observed.
子宫内的不良暴露可能会导致心血管和代谢器官发育的适应性变化，使个体从童年起就易患不良的心脏代谢风险状况。我们假设代谢途径的适应性变化是这些关联的基础，并研究了出生时的代谢物谱与儿童心脏代谢风险因素之间的关联。
该研究纳入了763对母婴，他们参与了一项正在进行的基于人群的前瞻性队列研究，总体疾病风险较低。使用液相色谱-串联质谱法测定脐血血清中氨基酸（AAs）、非酯化脂肪酸、磷脂和肉碱（Carn）的浓度。我们在儿童5.9（0.3）岁和9.8（0.9）岁时测量了腹部/臀部脂肪量比、血压、胰岛素和血脂浓度。
我们未观察到脐血代谢物与两个年龄段的收缩压或舒张压、胰岛素、甘油三酯以及腹部/臀部脂肪量比之间的关联，也未观察到10岁时的心脏代谢风险聚集情况。5种短链和中链Carn.a代谢物与6岁时的心脏代谢风险聚集呈正相关，但在更严格的混杂因素调整后未留存。
未观察到脐血代谢物与学龄期心血管危险因素之间存在一致的关联。
