Cordera R, Viviani G, Odetti P, De Micheli A, Corsi L, Maiello M, Bordone C, Prando R
Boll Soc Ital Biol Sper. 1979 Jun 30;55(11):1111-6.
We studied the E.I.R. in eight normal subjects and fifteen obese ones with three successive small glucose pulses (5 g.) e.v. at 30' interval. In normal subjects the three successive loads gave rise to identical responses for both glucose and I.R.I. Obese could be divided, on the basis of their E.I.R. to the first load, into normal responders (group I), hyper-responders (group II) and hypo-résponders (group III); on the basis of the E.I.R. to the second load, group I could be divided in two subgroups: Ia and Ib. We found an identical E.I.R. to all glucose loads in group Ia; a reduced E.I.R. to successive loads in groups Ib and II. Group III didn't have any insulin response to all glucose loads.
我们对8名正常受试者和15名肥胖受试者进行了研究，通过静脉内每隔30分钟连续给予三次小剂量葡萄糖脉冲（5克）来测定早期胰岛素反应（E.I.R.）。在正常受试者中，三次连续负荷对葡萄糖和胰岛素释放免疫反应（I.R.I.）均产生相同反应。肥胖受试者根据其对首次负荷的早期胰岛素反应可分为正常反应者（I组）、高反应者（II组）和低反应者（III组）；根据对第二次负荷的早期胰岛素反应，I组可分为两个亚组：Ia和Ib。我们发现Ia组对所有葡萄糖负荷的早期胰岛素反应相同；Ib组和II组对连续负荷的早期胰岛素反应降低。III组对所有葡萄糖负荷均无胰岛素反应。
