Prando R, Cordera R, Odetti P, De Micheli A, Maiello M, Viviani G, Adezati L
Acta Diabetol Lat. 1978 Jan-Apr;15(1-2):53-67. doi: 10.1007/BF02581007.
Two 5 g glucose loads at 1-h interval were given to healthy controls and obese subjects with slightly altered or normal OGTT in order to explore the capacity of restoration of the "rapid insulin response" to i.v. glucose. In the normal subjects, the two successive loads gave rise to identical responses as far as maximum increase (delta max), average increase at 2-5 min (delta 2-5 min), area of increase 0-15 min (delta 0-15 min) for both glucose and IRI, were concerned. Obese subjects could be divided on the basis of their insulin response to the first load into normal responders (group I) and high-responders (group II). In group I obese subjects, the responses to the second load were identical to those to the first. In group II obese subjects delta max, delta 2-5 min and delta 0-15 min of the insulin response to the second load were reduced as compared to the first.
为了探究静脉注射葡萄糖后“快速胰岛素反应”的恢复能力，对健康对照组以及口服葡萄糖耐量试验（OGTT）略有改变或正常的肥胖受试者给予两次间隔1小时的5克葡萄糖负荷。在正常受试者中，就葡萄糖和胰岛素释放指数（IRI）的最大增加量（δ最大值）、2 - 5分钟的平均增加量（δ2 - 5分钟）、0 - 15分钟的增加面积（δ0 - 15分钟）而言，两次连续的负荷产生了相同的反应。肥胖受试者可根据其对第一次负荷的胰岛素反应分为正常反应者（第一组）和高反应者（第二组）。在第一组肥胖受试者中，对第二次负荷的反应与对第一次的反应相同。在第二组肥胖受试者中，与第一次相比，第二次负荷的胰岛素反应的δ最大值、δ2 - 5分钟和δ0 - 15分钟均降低。
