Shao Ya, Wang Na, Shao Meiling, Liu Bin, Wang Yu, Yang Yan, Li Longti, Zhong Huiqin
Health Management Center, TaiHe Hospital, Hubei University of Medicine, Wudangshan Campus, Shiyan, Hubei, China.
Innovation Centre of Nursing Research, TaiHe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Sci Rep. 2025 Jan 27;15(1):3422. doi: 10.1038/s41598-025-88167-1.
The literature has documented conflicting and inconsistent associations between muscle-to-fat ratios and metabolic diseases. Additionally, different adipose tissues can have contrasting effects, with visceral adipose tissue being identified as particularly harmful. This study aimed to explore the relationship between the ratio of the lean mass index (LMI) to the visceral fat mass index (VFMI) and cardiometabolic disorders, including dyslipidemia, hypertension, and diabetes, as previous research on this topic is lacking. This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted in the United States and included 10,867 individuals. Logistic regression was employed to explore the association between LMI/VFMI and cardiometabolic disorders. Generalized additive models were utilized to examine the nonlinear relationships between variables. Data analysis revealed a consistent inverse association between ln(LMI/VFMI) and dyslipidemia, hypertension, and diabetes. Each 2.7-fold increase in LMI/VFMI (one unit of ln[LMI/VFMI]) was associated with lower odds ratios (ORs) for these conditions. In men, the ORs were 0.21 (95% CI 0.17-0.25) for dyslipidemia, 0.37 (95% CI 0.30-0.45) for hypertension, and 0.16 (95% CI 0.10-0.23) for diabetes. Similarly, in women, the ORs were 0.22 (95% CI 0.19-0.26), 0.51 (95% CI 0.42-0.61), and 0.19 (95% CI 0.13-0.27). Quartile analysis showed that participants in the highest quartile (Q4) had significantly lower ORs compared to those in the lowest quartile (Q1). In men, Q4 ORs were 0.18 (95% CI 0.14-0.23) for dyslipidemia, 0.30 (95% CI 0.23-0.39) for hypertension, and 0.11 (95% CI 0.06-0.20) for diabetes. In women, Q4 ORs were 0.12 (95% CI 0.10-0.15), 0.39 (95% CI 0.29-0.52), and 0.12 (95% CI 0.06-0.25), respectively. Dyslipidemia and diabetes demonstrated nonlinear patterns, while a linear association was found for hypertension. Subgroup analyses across various characteristics confirmed these findings with no substantial directional changes. Maintaining an appropriate ratio of LMI to VFMI may be associated with favorable metabolic health.
文献记载了肌肉与脂肪比例和代谢性疾病之间相互矛盾且不一致的关联。此外，不同的脂肪组织可能有相反的作用，其中内脏脂肪组织被认为特别有害。由于此前缺乏关于这一主题的研究，本研究旨在探讨瘦体重指数（LMI）与内脏脂肪质量指数（VFMI）的比值与心血管代谢紊乱（包括血脂异常、高血压和糖尿病）之间的关系。这项横断面研究利用了美国国家健康与营养检查调查（NHANES）的数据，纳入了10867名个体。采用逻辑回归来探讨LMI/VFMI与心血管代谢紊乱之间的关联。利用广义相加模型来检验变量之间的非线性关系。数据分析显示ln（LMI/VFMI）与血脂异常、高血压和糖尿病之间存在一致的负相关。LMI/VFMI每增加2.7倍（ln[LMI/VFMI]增加一个单位）与这些疾病的较低比值比（OR）相关。在男性中，血脂异常的OR为0.21（95%CI 0.17 - 0.25），高血压的OR为0.37（95%CI 0.30 - 0.45），糖尿病的OR为0.16（95%CI 0.10 - 0.23）。同样，在女性中，OR分别为0.
