Greenwood B M, Mohammed I, Whittle H C
Clin Exp Immunol. 1985 Mar;59(3):513-9.
Immune complex levels were measured in serum and synovial fluid obtained from 10 patients who developed arthritis 3-8 days after the onset of meningococcal meningitis. Mean serum immune complex levels were lower in these patients than in eight age matched control patients with meningococcal disease who did not develop late complications. This observation suggests that meningococcal arthritis follows local formation of immune complexes in the synovium rather than deposition of circulating immune complexes. Purified meningococcal polysaccharide antigen-induced synovitis when injected into the knee of rabbits previously sensitized by i.v. injection with heat killed meningococci.
在10例脑膜炎球菌性脑膜炎发病3 - 8天后出现关节炎的患者所获得的血清和滑液中检测免疫复合物水平。这些患者的平均血清免疫复合物水平低于8例年龄匹配的患脑膜炎球菌病但未发生晚期并发症的对照患者。这一观察结果提示，脑膜炎球菌性关节炎是滑膜中免疫复合物的局部形成所致，而非循环免疫复合物的沉积。当将纯化的脑膜炎球菌多糖抗原注射到先前经静脉注射热灭活脑膜炎球菌致敏的兔膝关节时，可诱发滑膜炎。
