Umeda F, Franks D J, Sugimoto H, Halle J P, Hamet P
Clin Invest Med. 1985;8(1):35-40.
Abnormalities in the regulation of proliferation of vascular smooth muscle are believed to be involved in the development of atherosclerosis. This study addresses the question of whether altered levels or activity of circulating factors in diabetes may influence the growth of vascular smooth muscle cells and fibroblasts. Plasma prepared from a group of patients with insulin-dependent diabetes mellitus was less capable of stimulating DNA synthesis in cultured vascular smooth muscle cells and human lung fibroblasts than plasma from control subjects. In contrast a platelet lysate prepared from the same patients caused significantly greater DNA synthesis than did a platelet lysate prepared from the controls. Thus both increased and decreased growth promoting activity exist in diabetes. The end result of these abnormalities may depend on the sensitivity of the target organ and platelet function, but may be related to the increased risk of atherosclerosis amongst the diabetic population.
血管平滑肌增殖调节异常被认为与动脉粥样硬化的发展有关。本研究探讨了糖尿病患者循环因子水平或活性的改变是否会影响血管平滑肌细胞和成纤维细胞的生长。与对照组受试者的血浆相比，一组胰岛素依赖型糖尿病患者的血浆刺激培养的血管平滑肌细胞和人肺成纤维细胞中DNA合成的能力较弱。相比之下，同一组患者制备的血小板裂解物比对照组制备的血小板裂解物引起的DNA合成显著增加。因此，糖尿病中既存在生长促进活性增加，也存在生长促进活性降低的情况。这些异常的最终结果可能取决于靶器官的敏感性和血小板功能，但可能与糖尿病患者动脉粥样硬化风险增加有关。
