Op de Coul A A, Lambregts P C, Koeman J, van Puyenbroek M J, Ter Laak H J, Gabreëls-Festen A A
Clin Neurol Neurosurg. 1985;87(1):17-22. doi: 10.1016/0303-8467(85)90060-5.
This paper reports on 12 patients in a 3-year period (from 1st July 1980 to 1st July 1983) who were treated with artificial ventilation and with the muscle relaxant pancuronium bromide (Pavulon), over a period of 6 days or longer. After discontinuation of this drug these patients developed severe tetraparesis with areflexia, sometimes combined with disturbances of the extraocular and facial muscles and diffuse muscular atrophy, without sensory disturbances. Seven patients recovered completely after 2-5 months, two made an incomplete recovery and three died due to the primary disease. It is suggested that these neuromuscular complications were caused by prolonged high-dosage Pavulon treatment in combination with renal and hepatic disturbances and/or the use of aminoglucosides.
本文报告了在3年期间（从1980年7月1日至1983年7月1日）接受人工通气及肌肉松弛剂潘库溴铵（巴夫龙）治疗6天或更长时间的12例患者。停用该药后，这些患者出现了严重的四肢轻瘫伴反射消失，有时合并眼外肌和面肌功能障碍及弥漫性肌肉萎缩，无感觉障碍。7例患者在2至5个月后完全康复，2例恢复不完全，3例因原发病死亡。提示这些神经肌肉并发症是由长期高剂量使用潘库溴铵治疗，合并肾、肝损害和/或使用氨基糖苷类药物所致。
