Kamp H H, Bär P R, van den Doel E H, Elderson A
Clin Neurol Neurosurg. 1985;87(1):3-10. doi: 10.1016/0303-8467(85)90058-7.
Multiple sclerosis (MS) remains a diagnosis based mainly on clinical criteria. Definitive diagnostic tests are, despite numerous attempts, not available. However, some laboratory tests like electrophoresis of the cerebrospinal fluid proteins or the determination of immunoglobulin G in cerebrospinal fluid have proved useful in increasing the probability of MS. This paper describes how these laboratory tests have to be interpreted in relation to pathophysiological phenomena and how they correlate with each other. The electrophoresis of CSF proteins and the diagnostic quotients (Ralb and CSF-IgG-index) are valuable aids to the clinician. It especially can substantiate the diagnosis MS. The magnitude of the index cannot be correlated with the clinical stage of MS. The usefulness of these tests in terms of a possible gain of information in the diagnostic process is discussed.
多发性硬化症（MS）的诊断目前仍主要基于临床标准。尽管经过多次尝试，但仍未找到确诊的诊断测试方法。然而，一些实验室检查，如脑脊液蛋白电泳或脑脊液中免疫球蛋白G的测定，已被证明有助于提高MS的诊断概率。本文描述了这些实验室检查结果如何根据病理生理现象进行解读，以及它们之间的相互关系。脑脊液蛋白电泳和诊断指数（Ralb和脑脊液IgG指数）对临床医生来说是有价值的辅助手段，尤其有助于确诊MS。该指数的大小与MS的临床阶段并无关联。本文还讨论了这些检查在诊断过程中可能获取的信息方面的有用性。
