Geest Andreas, Bonnesen Barbara, Jordan Alexander, Tønnesen Louise, Rømer Valdemar, Ulrik Charlotte S, Harboe Zitta, Eklöf Josefin, Sivapalan Pradeesh, Jensen Jens-Ulrik Stæhr
Copenhagen Respiratory Research (COP:RESP), Department of Internal Medicine, Herlev-Gentofte University Hospital, Hellerup, Denmark.
Department of Respiratory Medicine, Copenhagen University Hospital - Hvidovre, Hvidovre, Denmark.
Eur Psychiatry. 2025 Jan 28;68(1):e30. doi: 10.1192/j.eurpsy.2025.5.
Current knowledge on psychiatric illness following periods of social distancing during the COVID-19 pandemic is mostly limited to smaller studies in selected populations. This nationwide study of all 4.6 million Danish adults examined if periods of social distancing were associated with changes in surrogate measures of mental health.
All Danish adults (≥18 years) were included and rates of collection of antidepressant prescriptions, psychiatric hospital admissions, and suicide or suicide attempts for the periods March 12, 2020-May 20, 2020 (lockdown period 1), and December 21, 2020-March 1, 2021 (lockdown period 2), were compared to corresponding periods 1 year prior. Individuals were censored due to death or SARS-CoV-2 infection.
Antidepressant consumption increased for both period 1 and period 2, with an incidence rate ratio (IRR) of 1.02 (95% CI: 1.01-1.02, < 0.001) and IRR 1.08 (95% CI: 1.08-1.09 < 0.001) respectively, compared to the control periods. Psychiatric hospitalization rates decreased significantly, with an IRR of 0.65 (95% CI: 0.63-0.66, < 0.001) for period 1, and IRR 0.86 (95% CI: 0.84-0.88, < 0.001) for period 2. The risk of suicide did not increase in period 1, IRR 0.96 (95% CI: 0.82-1.13, = 0.64), but seemed increased during period 2, IRR 1.19 (95% CI: 1.02-1.38, = 0.03).
Periods of social distancing during the COVID-19 pandemic were associated with an increase of antidepressant consumption, but decreased rates of psychiatric hospitalization. Suicide risk seemed increased during the second lockdown period.
目前关于新冠疫情期间社交隔离后精神疾病的认知大多局限于特定人群的小型研究。这项针对丹麦460万成年人的全国性研究，调查了社交隔离期是否与心理健康替代指标的变化有关。
纳入所有丹麦成年人（≥18岁），并比较了2020年3月12日至2020年5月20日（封锁期1）以及2020年12月21日至2021年3月1日（封锁期2）期间抗抑郁药处方的开具率、精神病住院率以及自杀或自杀未遂率与前一年相应时期的情况。个体因死亡或感染新冠病毒而被审查。
与对照期相比，封锁期1和封锁期2的抗抑郁药消耗量均有所增加，发病率比值（IRR）分别为1.02（95%置信区间：1.01 - 1.02，<0.001）和1.08（95%置信区间：1.08 - 1.09，<0.001）。精神病住院率显著下降，封锁期1的IRR为0.65（95%置信区间：0.63 - 0.66，<0.001），封锁期2的IRR为0.86（95%置信区间：0.84 - 0.88，<0.001）。封锁期1的自杀风险没有增加，IRR为0.96（95%置信区间：0.82 - 1.13，P = 0.64），但在封锁期2似乎有所增加，IRR为1.19（95%置信区间：1.02 - 1.38，P = 0.03）。
新冠疫情期间的社交隔离期与抗抑郁药消耗量增加有关，但精神病住院率下降。在第二次封锁期自杀风险似乎有所增加。
