Wang Shudan, Feng Jiaoyang, Zhu Rui, Jin Xin, Ding Yiheng, Jin Di, Guo Yu, Zhang Hong
Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Front Med (Lausanne). 2025 Jan 13;11:1292821. doi: 10.3389/fmed.2024.1292821. eCollection 2024.
This study aimed to report the ocular manifestations in individuals with coronavirus disease 2019 (COVID-19) and investigate any correlation between the occurrence of ocular symptoms and systemic symptoms.
A retrospective electronic survey was conducted among the general public in northern China from December 2022 through February 2023. Inclusion criteria for COVID-19 was confirmed testing positive via a polymerase chain reaction (PCR) test or testing positive for COVID-19 via an antigen kit. The anonymous survey collected information on demographics, systemic COVID-19 symptoms, ocular diagnosis and symptoms, comorbidities and disease history.
A total of 2,405 survey responses were collected and the final analysis included individuals in the 335 COVID-19 positive group and 434 individuals in the COVID-19 negative group. Among COVID-19 positive patients 66.3% ( = 222) reported experiencing ocular symptoms. Dryness ( = 106, 31.6%), blurred vision ( = 81, 24.2%), eye pain ( = 72, 21.5%), and itching ( = 71, 21.2%) were the main features. COVID-19 was found to be associated with a higher prevalence of conjunctivitis, iritis, uveitis, retinal vein occlusion and optic neuritis. The majority of individuals (51.0%) developed eye symptoms after the onset of COVID-19 systemic symptoms. There was no significant association between the severity of systemic symptoms and ocular symptoms.
Individuals with COVID-19 were significantly more likely to experience ocular symptoms. COVID-19 was found to be associated with a higher prevalence of retinal diseases. The majority of individuals developed ocular symptoms right after the onset of systemic symptoms.
本研究旨在报告2019冠状病毒病（COVID-19）患者的眼部表现，并调查眼部症状与全身症状之间的相关性。
于2022年12月至2023年2月在中国北方的普通人群中进行了一项回顾性电子调查。COVID-19的纳入标准是通过聚合酶链反应（PCR）检测确诊为阳性，或通过抗原试剂盒检测出COVID-19呈阳性。这项匿名调查收集了有关人口统计学、COVID-19全身症状、眼部诊断和症状、合并症和疾病史的信息。
共收集到2405份调查回复，最终分析包括335名COVID-19阳性组个体和434名COVID-19阴性组个体。在COVID-19阳性患者中，66.3%（n = 222）报告有眼部症状。主要特征包括眼干（n = 106，31.6%）、视力模糊（n = 81，24.2%）、眼痛（n = 72，21.5%）和眼痒（n = 71，21.2%）。发现COVID-19与结膜炎、虹膜炎、葡萄膜炎、视网膜静脉阻塞和视神经炎的较高患病率相关。大多数个体（51.0%）在COVID-19全身症状出现后出现眼部症状。全身症状的严重程度与眼部症状之间无显著关联。
COVID-19患者出现眼部症状的可能性显著更高。发现COVID-19与视网膜疾病的较高患病率相关。大多数个体在全身症状出现后立即出现眼部症状。
