Majeed Ammara A, Butt Amna S
Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan.
World J Hepatol. 2025 Jan 27;17(1):100968. doi: 10.4254/wjh.v17.i1.100968.
Due to sedentary lifestyle and rising prevalence of obesity, patients with general population and those who are infected with chronic hepatitis B are found to have metabolic dysfunction associated steatotic liver disease (MASLD). Both chronic hepatitis B virus (HBV) infection and MASLD can damage hepatocytes in their own way, but concomitant HBV-MASLD has its own clinical implications. Cherry on top is the presence of diabetes mellitus, hypertension or obesity which added more chances of unfavorable outcomes in these patients. In this article, we comment on the article by Wang published in the recent issue. This article provides a comprehensive overview of the complex interaction between HBV-MASLD, HBV alone and MASLD alone patients. We discuss key findings from recent studies, including the promising outcomes observed in patients with concurrent HBV and MASLD, warrants further research. The insights presented here offer renewed understanding of this complex interaction.
由于久坐不动的生活方式以及肥胖患病率的上升，普通人群以及慢性乙型肝炎感染者中均发现存在代谢功能障碍相关脂肪性肝病（MASLD）。慢性乙型肝炎病毒（HBV）感染和MASLD均可通过各自的方式损害肝细胞，但HBV-MASLD并存有其自身的临床意义。更糟糕的是，糖尿病、高血压或肥胖的存在增加了这些患者出现不良结局的几率。在本文中，我们对王[作者姓氏]近期发表的文章进行评论。本文全面概述了HBV-MASLD患者、单纯HBV感染者和单纯MASLD患者之间的复杂相互作用。我们讨论了近期研究的主要发现，包括在HBV和MASLD并存患者中观察到的有前景的结果，这些结果值得进一步研究。本文所阐述的见解为这种复杂的相互作用提供了新的认识。
