Morales-Galicia Arnulfo E, Ramírez-Mejía Mariana M, Ponciano-Rodriguez Guadalupe, Méndez-Sánchez Nahum
Faculty of Medicine, National Autonomous University of Mexico, Mexico City 04360, Mexico.
Plan of Combined Studies in Medicine, Faculty of Medicine, National Autonomous University of Mexico, Mexico City 04360, Mexico.
World J Hepatol. 2024 Dec 27;16(12):1365-1370. doi: 10.4254/wjh.v16.i12.1365.
The intersection between metabolic-associated steatotic liver disease (MASLD) and chronic hepatitis B virus (HBV) infection is an emerging area of research with significant implications for public health and clinical practice. Wang 's study highlights the complexities of managing patients with concurrent MASLD and HBV. The findings revealed that patients with concurrent MASLD-HBV exhibited more severe liver inflammation and fibrosis, whereas those with HBV alone presented a better lipid profile. The growing recognition of metabolic dysfunction in liver disease, reflected in the shift from nonalcoholic liver disease to MASLD, demands updates to clinical guidelines, particularly for patients with dual etiologies. Understanding the biological interactions between MASLD and HBV could lead to novel therapeutic approaches, emphasizing the need for personalized treatment strategies. The coexistence of MASLD and HBV presents therapeutic challenges, particularly in managing advanced fibrosis and cirrhosis, which are more likely in these patients. The aim of this editorial is to analyze the interaction between MASLD and HBV, highlight the pathophysiological mechanisms that exacerbate liver disease when both conditions coexist, and discuss the clinical implications of the findings of Wang .
代谢相关脂肪性肝病（MASLD）与慢性乙型肝炎病毒（HBV）感染之间的交叉领域是一个新兴的研究领域，对公共卫生和临床实践具有重大意义。王的研究突出了同时患有MASLD和HBV的患者管理的复杂性。研究结果显示，同时患有MASLD-HBV的患者表现出更严重的肝脏炎症和纤维化，而仅患有HBV的患者血脂状况较好。从非酒精性肝病到MASLD的转变反映出对肝病中代谢功能障碍的认识不断增加，这需要更新临床指南，特别是针对具有双重病因的患者。了解MASLD和HBV之间的生物学相互作用可能会带来新的治疗方法，强调了个性化治疗策略的必要性。MASLD和HBV的共存带来了治疗挑战，特别是在管理这些患者中更易出现的晚期纤维化和肝硬化方面。本社论的目的是分析MASLD和HBV之间的相互作用，突出两种情况共存时加剧肝病的病理生理机制，并讨论王的研究结果的临床意义。
