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2型糖尿病中代谢功能障碍相关脂肪性肝病的高患病率:迫切需要综合筛查和生活方式干预。

High metabolic dysfunction-associated steatotic liver disease prevalence in type 2 diabetes: Urgent need for integrated screening and lifestyle intervention.

作者信息

Jin Lei-Yang, Wang Kai, Xu Bo-Tao

机构信息

Department of Hepatobiliary Surgery, Zhuji People's Hospital, Zhuji 311800, Zhejiang Province, China.

Department of Cardiothoracic Surgery, Zhuji People's Hospital, Zhuji 311800, Zhejiang Province, China.

出版信息

World J Hepatol. 2025 Jan 27;17(1):103409. doi: 10.4254/wjh.v17.i1.103409.

DOI:10.4254/wjh.v17.i1.103409
PMID:39871905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11736486/
Abstract

This letter discusses the recent study by Mukherjee , which identifies a significant prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) among newly diagnosed type 2 diabetes mellitus (T2DM) patients in Bihar, India, and underscores the pressing need for integrated MASLD management within T2DM care. With 72.3% of the study cohort affected by MASLD, implementing routine liver function tests and ultrasound screenings is recommended as a standard practice in diabetes care, especially in regions with high prevalence rates. The study also advocates for dietary and lifestyle modifications, particularly the reduction of saturated fats, to slow MASLD progression. Patient education on monitoring body mass index and waist circumference, coupled with the integration of these metrics into digital health records, could enhance patient involvement and support proactive health management. Moreover, the letter emphasizes the advantages of developing a region-specific MASLD risk model that incorporates local dietary patterns and socioeconomic factors. Continued research into genetic and environmental determinants of MASLD remains essential for advancing our understanding of its etiology and informing targeted public health strategies.

摘要

这封信讨论了穆克吉最近的一项研究,该研究发现印度比哈尔邦新诊断的2型糖尿病(T2DM)患者中,代谢功能障碍相关脂肪性肝病(MASLD)的患病率很高,并强调在T2DM护理中迫切需要对MASLD进行综合管理。该研究队列中有72.3%的患者受MASLD影响,建议将进行常规肝功能检查和超声筛查作为糖尿病护理的标准做法,尤其是在患病率高的地区。该研究还提倡进行饮食和生活方式的改变,特别是减少饱和脂肪的摄入,以减缓MASLD的进展。对患者进行关于监测体重指数和腰围的教育,并将这些指标纳入数字健康记录中,可提高患者的参与度并支持积极的健康管理。此外,这封信强调了开发一个纳入当地饮食模式和社会经济因素的特定区域MASLD风险模型的优势。继续研究MASLD的遗传和环境决定因素对于增进我们对其病因的理解并为有针对性的公共卫生策略提供依据仍然至关重要。

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