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Local hyperthermia therapy: a novel strategy turning white fat brown.

作者信息

Xu Lingyan, Li Yu, Finkel Toren, Ma Xinran

机构信息

Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai 200241, China.

Aging Institute, University of Pittsburgh School of Medicine/University of Pittsburgh Medical Center, Pittsburgh, PA 15219, United States.

出版信息

Life Med. 2022 Jun 24;1(2):78-80. doi: 10.1093/lifemedi/lnac005. eCollection 2022 Oct.

DOI:10.1093/lifemedi/lnac005
PMID:39871919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11749632/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dd/11749632/381be9683d1a/lnac005_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dd/11749632/381be9683d1a/lnac005_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2dd/11749632/381be9683d1a/lnac005_fig1.jpg

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本文引用的文献

1
Local hyperthermia therapy induces browning of white fat and treats obesity.局部热疗诱导白色脂肪棕色化并治疗肥胖症。
Cell. 2022 Mar 17;185(6):949-966.e19. doi: 10.1016/j.cell.2022.02.004. Epub 2022 Mar 4.
2
Thermal and cardiovascular responses and thermal sensation during hot-water bathing and the influence of room temperature.热水浴时的热生理和心血管反应及热感觉与室温的影响
J Therm Biol. 2019 May;82:83-89. doi: 10.1016/j.jtherbio.2019.03.014. Epub 2019 Mar 26.
3
Heat shock protein 72 regulates hepatic lipid accumulation.
热休克蛋白72调节肝脏脂质积累。
Am J Physiol Regul Integr Comp Physiol. 2018 Oct 1;315(4):R696-R707. doi: 10.1152/ajpregu.00073.2018. Epub 2018 Jun 20.
4
The transcriptional coactivator PGC1α protects against hyperthermic stress via cooperation with the heat shock factor HSF1.转录共激活因子PGC1α通过与热休克因子HSF1协同作用来抵御热应激。
Cell Death Dis. 2016 Feb 18;7(2):e2102. doi: 10.1038/cddis.2016.22.
5
Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans.烧伤会导致小鼠和人类皮下白色脂肪组织褐变。
Cell Rep. 2015 Nov 24;13(8):1538-44. doi: 10.1016/j.celrep.2015.10.028. Epub 2015 Nov 12.
6
Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis.藜芦醇通过激活 HSF1-PGC1α 转录轴来预防肥胖和代谢功能障碍。
Cell Metab. 2015 Oct 6;22(4):695-708. doi: 10.1016/j.cmet.2015.08.005. Epub 2015 Sep 3.
7
Mitohormesis.线粒体细胞自噬。
Cell Metab. 2014 May 6;19(5):757-66. doi: 10.1016/j.cmet.2014.01.011. Epub 2014 Feb 20.
8
Fat cells directly sense temperature to activate thermogenesis.脂肪细胞能直接感知温度以激活产热。
Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12480-5. doi: 10.1073/pnas.1310261110. Epub 2013 Jul 1.
9
Lack of an effect of a novel beta3-adrenoceptor agonist, TAK-677, on energy metabolism in obese individuals: a double-blind, placebo-controlled randomized study.新型β3肾上腺素能受体激动剂TAK-677对肥胖个体能量代谢无影响：一项双盲、安慰剂对照的随机研究。
J Clin Endocrinol Metab. 2007 Feb;92(2):527-31. doi: 10.1210/jc.2006-1740. Epub 2006 Nov 21.
10
Hot-tub therapy for type 2 diabetes mellitus.2型糖尿病的热水浴疗法。
N Engl J Med. 1999 Sep 16;341(12):924-5. doi: 10.1056/NEJM199909163411216.