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Glutathione restoration: a sword to combat skeletal muscle stem cell aging.

作者信息

Wu Zeming, Ren Jie, Liu Guang-Hui

机构信息

State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.

出版信息

Life Metab. 2023 Mar 31;2(3):load012. doi: 10.1093/lifemeta/load012. eCollection 2023 Jun.

DOI:10.1093/lifemeta/load012
PMID:39872012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11749860/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7664/11749860/24656928ad4e/load012_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7664/11749860/24656928ad4e/load012_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7664/11749860/24656928ad4e/load012_fig1.jpg

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本文引用的文献

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Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging.多组学揭示谷胱甘肽代谢是干细胞衰老过程中双峰性的驱动因素。
Cell Metab. 2023 Mar 7;35(3):472-486.e6. doi: 10.1016/j.cmet.2023.02.001. Epub 2023 Feb 27.
2
Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle.蛋氨酸腺苷转移酶 2A 抑制作用恢复代谢,改善老年骨骼肌的再生能力和力量。
Nat Commun. 2023 Feb 16;14(1):886. doi: 10.1038/s41467-023-36483-3.
3
Mitochondrial and metabolic dysfunction in ageing and age-related diseases.
衰老及年龄相关疾病中的线粒体与代谢功能障碍
Nat Rev Endocrinol. 2022 Apr;18(4):243-258. doi: 10.1038/s41574-021-00626-7. Epub 2022 Feb 10.
4
Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and lifespan in mice.终身限制饮食中支链氨基酸可特异性改善雌雄小鼠的虚弱和寿命。
Nat Aging. 2021 Jan;1(1):73-86. doi: 10.1038/s43587-020-00006-2. Epub 2021 Jan 14.
5
The balance between NRF2/GSH antioxidant mediated pathway and DNA repair modulates cisplatin resistance in lung cancer cells.NRF2/GSH 抗氧化介导途径与 DNA 修复之间的平衡调节肺癌细胞对顺铂的耐药性。
Sci Rep. 2019 Nov 27;9(1):17639. doi: 10.1038/s41598-019-54065-6.
6
Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism.蛋氨酸限制延长早衰小鼠寿命并改变脂质和胆汁酸代谢。
Cell Rep. 2018 Aug 28;24(9):2392-2403. doi: 10.1016/j.celrep.2018.07.089.
7
NF-κB in Aging and Disease.NF-κB 在衰老和疾病中的作用。
Aging Dis. 2011 Dec;2(6):449-65. Epub 2011 Dec 2.
8
Glutathione: overview of its protective roles, measurement, and biosynthesis.谷胱甘肽:其保护作用、测量方法及生物合成的概述
Mol Aspects Med. 2009 Feb-Apr;30(1-2):1-12. doi: 10.1016/j.mam.2008.08.006. Epub 2008 Aug 30.
9
Age-related changes in glutathione availability and skeletal muscle carbonyl content in healthy rats.健康大鼠体内谷胱甘肽可用性及骨骼肌羰基含量的年龄相关变化。
Exp Gerontol. 2004 Feb;39(2):203-10. doi: 10.1016/j.exger.2003.10.014.
10
Inhibition of NADP dependent oxidoreductases by the 6-aminonicotinamide analogue of NADP.NADP的6-氨基烟酰胺类似物对依赖NADP的氧化还原酶的抑制作用。
FEBS Lett. 1970 Feb 16;6(3):225-228. doi: 10.1016/0014-5793(70)80063-1.