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终身限制饮食中支链氨基酸可特异性改善雌雄小鼠的虚弱和寿命。

Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and lifespan in mice.

机构信息

Department of Medicine, University of Wisconsin-Madison, Madison, WI.

William S. Middleton Memorial Veterans Hospital, Madison, WI.

出版信息

Nat Aging. 2021 Jan;1(1):73-86. doi: 10.1038/s43587-020-00006-2. Epub 2021 Jan 14.

DOI:10.1038/s43587-020-00006-2
PMID:33796866
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8009080/
Abstract

Protein restricted (PR) diets promote health and longevity in many species. While the precise components of a PR diet that mediate the beneficial effects to longevity have not been defined, we recently showed that many metabolic effects of PR can be attributed to reduced dietary levels of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine. Here, we demonstrate that restricting dietary BCAAs increases the survival of two different progeroid mouse models, delays frailty and promotes the metabolic health of wild-type C57BL/6J mice when started in midlife, and leads to a 30% increase in lifespan and a reduction in frailty in male, but not female, wild-type mice when fed lifelong. Our results demonstrate that restricting dietary BCAAs can increase healthspan and longevity in mice, and suggest that reducing dietary BCAAs may hold potential as a translatable intervention to promote healthy aging.

摘要

限制蛋白质（PR）饮食可促进许多物种的健康和长寿。虽然尚不清楚介导 PR 对长寿有益影响的确切 PR 饮食成分，但我们最近发现 PR 的许多代谢效应可归因于降低膳食支链氨基酸（BCAAs）亮氨酸、异亮氨酸和缬氨酸的水平。在这里，我们证明限制饮食中的 BCAAs 可提高两种不同的早衰小鼠模型的存活率，延缓虚弱，并促进中年开始的野生型 C57BL/6J 小鼠的代谢健康，当终生喂养时，可使雄性而非雌性野生型小鼠的寿命延长 30%并减少虚弱。我们的结果表明，限制饮食中的 BCAAs 可以增加小鼠的健康寿命和寿命，并表明减少饮食中的 BCAAs 可能具有作为促进健康衰老的可转化干预措施的潜力。

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