Wang Gai-Hua, Wang Yang-Bin, Cheng Yue-Ai, Chen Hong-Duo, Gao Xing-Hua, Qi Rui-Qun
Institute of Dermatology, Taiyuan City Centre Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, People's Republic of China.
Department of Dermatology, the First Hospital of China Medical University, Shenyang, Liaoning Province, People's Republic of China.
Clin Cosmet Investig Dermatol. 2025 Jan 23;18:241-244. doi: 10.2147/CCID.S504378. eCollection 2025.
Viral warts, a common dermatological condition caused by human papillomavirus infection (HPV) infection, present a particular challenge for systemic lupus erythematosus (SLE) patients due to their compromised immunity, which increases the susceptibility to HPV infection and complicates treatment efforts. Imiquimod, an immunomodulatory agent, has demonstrated efficacy in managing warts. Furthermore, local hyperthermia, a non-invasive therapeutic modality, has demonstrated significant potential in the management of warts. We report the case of a SLE patient developed recalcitrant and extensive viral warts on limbs. We applied hyperthermia at 45 °C on a target lesion for 1 hour / day with imiquimod cream 3 times/week. All the lesions cleared in 8 months and there was no sign of recurrence.
病毒性疣是由人乳头瘤病毒（HPV）感染引起的一种常见皮肤病，对于系统性红斑狼疮（SLE）患者而言是一项特殊挑战，因为他们免疫力受损，这增加了HPV感染的易感性并使治疗复杂化。咪喹莫特是一种免疫调节剂，已证明对治疗疣有效。此外，局部热疗作为一种非侵入性治疗方式，在疣的治疗中已显示出巨大潜力。我们报告了1例SLE患者四肢出现顽固性广泛性病毒性疣的病例。我们对一个靶病变部位每天进行1小时45℃的热疗，并每周3次外用咪喹莫特乳膏。所有病变在8个月内清除且无复发迹象。
