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Genome-wide CRISPR screens identify PTPN21 and WDR26 as modulators of the mitochondrial stress-induced ISR.

作者信息

Li Wen, Dong Mingyue, Gao Kaiyu, Guan Jialiang, Liu Ying

机构信息

State Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China.

Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.

出版信息

Life Metab. 2024 May 28;3(4):loae020. doi: 10.1093/lifemeta/loae020. eCollection 2024 Aug.

DOI:10.1093/lifemeta/loae020
PMID:39872503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11749115/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f157/11749115/bb386739ff8a/loae020_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f157/11749115/4598921a46c1/loae020_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f157/11749115/b44f12fd228a/loae020_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f157/11749115/0db11638f694/loae020_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f157/11749115/bb386739ff8a/loae020_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f157/11749115/4598921a46c1/loae020_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f157/11749115/b44f12fd228a/loae020_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f157/11749115/0db11638f694/loae020_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f157/11749115/bb386739ff8a/loae020_fig4.jpg

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本文引用的文献

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DELE1 tracks perturbed protein import and processing in human mitochondria.DELE1追踪人类线粒体中受干扰的蛋白质导入和加工过程。
Nat Commun. 2022 Apr 6;13(1):1853. doi: 10.1038/s41467-022-29479-y.
2
WD-40 repeat protein 26 protects against oxidative stress-induced injury in astrocytes via Nrf2/HO-1 pathways.WD-40 重复蛋白 26 通过 Nrf2/HO-1 通路保护星形胶质细胞免受氧化应激损伤。
Mol Biol Rep. 2022 Feb;49(2):1045-1056. doi: 10.1007/s11033-021-06925-6. Epub 2022 Jan 4.
3
The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress.
转录共激活因子 CBP/p300 是一个进化上保守的节点，它可以响应线粒体应激促进长寿。
Nat Aging. 2021 Feb;1(2):165-178. doi: 10.1038/s43587-020-00025-z. Epub 2021 Feb 8.
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Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity.组蛋白去乙酰化酶 HDA-1 调节线粒体应激反应和寿命。
Nat Commun. 2020 Sep 15;11(1):4639. doi: 10.1038/s41467-020-18501-w.
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The integrated stress response: From mechanism to disease.整体应激反应：从机制到疾病。
Science. 2020 Apr 24;368(6489). doi: 10.1126/science.aat5314.
6
Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.线粒体应激通过 OMA1-DELE1-HRI 途径传递到细胞质。
Nature. 2020 Mar;579(7799):427-432. doi: 10.1038/s41586-020-2078-2. Epub 2020 Mar 4.
7
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.由 DELE1 协调的途径将线粒体应激传递到细胞质。
Nature. 2020 Mar;579(7799):433-437. doi: 10.1038/s41586-020-2076-4. Epub 2020 Mar 4.
8
SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension.SUMO 肽酶 ULP-4 调节线粒体 UPR 介导的先天免疫和寿命延长。
Elife. 2019 Jan 15;8:e41792. doi: 10.7554/eLife.41792.
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The multifaceted contributions of mitochondria to cellular metabolism.线粒体对细胞代谢的多方面贡献。
Nat Cell Biol. 2018 Jul;20(7):745-754. doi: 10.1038/s41556-018-0124-1. Epub 2018 Jun 27.
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A Futile Battle? Protein Quality Control and the Stress of Aging.徒劳的战斗？蛋白质质量控制与衰老压力。
Dev Cell. 2018 Jan 22;44(2):139-163. doi: 10.1016/j.devcel.2017.12.020.