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本文引用的文献

1
Perioperative chemotherapy improves survival of patients with locally advanced diffuse gastric cancer.围手术期化疗可提高局部晚期弥漫性胃癌患者的生存率。
World J Gastrointest Surg. 2024 Sep 27;16(9):2878-2892. doi: 10.4240/wjgs.v16.i9.2878.
2
Multimodal Therapy Versus Primary Surgery for Gastric and Gastroesophageal Junction Diffuse Type Carcinoma, with a Focus on Signet Ring Cell Carcinoma: A Nationwide Study.多模态治疗与原发性手术治疗胃及胃食管交界处弥漫型癌，重点为印戒细胞癌：一项全国性研究。
Ann Surg Oncol. 2024 Mar;31(3):1760-1772. doi: 10.1245/s10434-023-14690-y. Epub 2023 Dec 21.
3
Epidemiology of stomach cancer.胃癌流行病学
World J Gastroenterol. 2022 Mar 28;28(12):1187-1203. doi: 10.3748/wjg.v28.i12.1187.
4
The Value of Perioperative Chemotherapy for Patients With Hepatoid Adenocarcinoma of the Stomach Undergoing Radical Gastrectomy.围手术期化疗对接受根治性胃切除术的胃肝样腺癌患者的价值。
Front Oncol. 2022 Jan 10;11:789104. doi: 10.3389/fonc.2021.789104. eCollection 2021.
5
PRODIGY: A Phase III Study of Neoadjuvant Docetaxel, Oxaliplatin, and S-1 Plus Surgery and Adjuvant S-1 Versus Surgery and Adjuvant S-1 for Resectable Advanced Gastric Cancer.PRODIGY 研究：新辅助多西他赛、奥沙利铂和 S-1 联合手术与手术联合辅助 S-1 治疗可切除的晚期胃癌的 III 期研究。
J Clin Oncol. 2021 Sep 10;39(26):2903-2913. doi: 10.1200/JCO.20.02914. Epub 2021 Jun 16.
6
A population-based study on intestinal and diffuse type adenocarcinoma of the oesophagus and stomach in the Netherlands between 1989 and 2015.一项基于人群的研究，针对的是 1989 年至 2015 年间荷兰的食管和胃的肠型和弥漫型腺癌。
Eur J Cancer. 2020 May;130:23-31. doi: 10.1016/j.ejca.2020.02.017. Epub 2020 Mar 11.
7
Individual Patient Data Meta-Analysis of the Value of Microsatellite Instability As a Biomarker in Gastric Cancer.胃癌中微卫星不稳定性作为生物标志物价值的个体化患者数据汇总分析。
J Clin Oncol. 2019 Dec 10;37(35):3392-3400. doi: 10.1200/JCO.19.01124. Epub 2019 Sep 12.
8
Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial.氟尿嘧啶+亚叶酸、奥沙利铂和多西紫杉醇与氟尿嘧啶或卡培他滨+顺铂和表柔比星用于局部晚期可切除胃或胃食管交界处腺癌的围手术期化疗（FLOT4）：一项随机、2/3 期试验。
Lancet. 2019 May 11;393(10184):1948-1957. doi: 10.1016/S0140-6736(18)32557-1. Epub 2019 Apr 11.
9
Comparable rates of lymph node metastasis and survival between diffuse type and intestinal type early gastric cancer patients: a large population-based study.弥漫型和肠型早期胃癌患者的淋巴结转移率和生存率相当：一项大型基于人群的研究。
Gastrointest Endosc. 2019 Jul;90(1):84-95.e10. doi: 10.1016/j.gie.2019.03.002. Epub 2019 Mar 15.
10
Clinical Significance of Four Molecular Subtypes of Gastric Cancer Identified by The Cancer Genome Atlas Project.癌症基因组图谱计划所鉴定的胃癌四种分子亚型的临床意义
Clin Cancer Res. 2017 Aug 1;23(15):4441-4449. doi: 10.1158/1078-0432.CCR-16-2211.

弥漫性胃癌的围手术期化疗策略

Perioperative chemotherapy strategies in diffuse gastric cancer.

作者信息

Salehi Niloufar, Alqamish Maria, Zarnegar Rasa

机构信息

Department of Surgery, Division of Endocrine & Minimally Invasive Surgery, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, NY 10128, United States.

出版信息

World J Gastrointest Surg. 2025 Jan 27;17(1):101326. doi: 10.4240/wjgs.v17.i1.101326.

DOI:10.4240/wjgs.v17.i1.101326
PMID:39872775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11757181/
Abstract

This study reviews the findings of a recent study by Li , which demonstrated that perioperative chemotherapy benefits patients with diffuse-type gastric cancer compared to surgery alone. Despite potential biases, the study supports the inclusion of perioperative chemotherapy in treatment guidelines. Neoadjuvant and adjuvant chemotherapy may also provide similar survival outcomes, allowing for flexible treatment planning.

摘要

本研究回顾了李近期的一项研究结果，该研究表明，与单纯手术相比，围手术期化疗对弥漫型胃癌患者有益。尽管存在潜在偏差，但该研究支持将围手术期化疗纳入治疗指南。新辅助化疗和辅助化疗也可能提供相似的生存结果，从而允许进行灵活的治疗规划。