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Establishment of novel colorectal cancer organoid model based on tumor microenvironment analysis.

作者信息

Xu Zhidong, Meng Shengwen, Xu Ran, Ma De, Dzakah Emmanuel Enoch, Zheng Hailun, Yao Tingjing, Ni Chao, Zhao Bing

机构信息

School of Basic Medical Sciences, The First Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang 330031, China.

State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China.

出版信息

Life Med. 2024 Jun 24;3(4):lnae027. doi: 10.1093/lifemedi/lnae027. eCollection 2024 Aug.

DOI:10.1093/lifemedi/lnae027
PMID:39872866
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11749256/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37aa/11749256/65e0b7af30a1/lnae027_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37aa/11749256/45a2c4ba0c60/lnae027_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37aa/11749256/65e0b7af30a1/lnae027_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37aa/11749256/45a2c4ba0c60/lnae027_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37aa/11749256/65e0b7af30a1/lnae027_fig2.jpg

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Gremlin1 is a therapeutically targetable FGFR1 ligand that regulates lineage plasticity and castration resistance in prostate cancer.Gremlin1 是一种可治疗的 FGFR1 配体，可调节前列腺癌中的谱系可塑性和去势抵抗。
Nat Cancer. 2022 May;3(5):565-580. doi: 10.1038/s43018-022-00380-3. Epub 2022 May 27.
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Genetic and biological hallmarks of colorectal cancer.
结直肠癌的遗传和生物学特征。
Genes Dev. 2021 Jun;35(11-12):787-820. doi: 10.1101/gad.348226.120.
4
Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer.谱系依赖性基因表达程序影响结直肠癌的免疫景观。
Nat Genet. 2020 Jun;52(6):594-603. doi: 10.1038/s41588-020-0636-z. Epub 2020 May 25.
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