Fardous Jannatul, Ara Anjuman, Hossain Md Iqbal, Labony Asma, Afrin Tanjila, Ashraf Rezwana, Uddin Reaz, Jesmin Habiba, Alam Md Kabir, Amin Mohammad Ashraful, Khan Anwar Hossain, Khan Zahid Hasan
National Institute of Kidney Diseases & Urology (NIKDU) Dhaka Bangladesh.
International Centre for Diarrheal Disease Research Bangladesh (icddr,b) Dhaka Bangladesh.
Health Sci Rep. 2025 Jan 26;8(1):e70406. doi: 10.1002/hsr2.70406. eCollection 2025 Jan.
Primary nocturnal enuresis (PNE) is a common pediatric condition characterized by involuntary nighttime bed wetting. Primary monosymptomatic nocturnal enuresis (PMNE) is associated with altered antidiuretic hormone (ADH) secretion and lacks lower urinary tract symptoms. This study aimed to compare serum ADH levels between children with PMNE and a comparison group to explore its potential role in the pathophysiology of PMNE.
This cross-sectional study included 40 children aged 6-15 years with PMNE and 40 age-matched children without enuresis (comparison group) attending the Pediatric Nephrology Outpatient Department at the National Institute of Kidney Diseases and Urology (NIKDU) from January 2022 to July 2023. Blood samples and other clinical information along with laboratory investigation are done to ensure inclusion and exclusion criteria. Fasting serum ADH level, a competitive immunoassay was done with the Arg- Vasopressin ELISA kit. Relevant clinical and demographic data were analyzed using Student's -test for continuous variables and Chi-square/Fisher's exact tests for categorical variables.
The mean age of participants was 8.82 ± 2.71 years in the PMNE group and 9.01 ± 2.54 years in the comparison group ( = 0.760). There was no significant association between sex and PMNE ( = 0.370). Children with PMNE exhibited significantly lower serum ADH levels compared to the comparison group ( < 0.05). Additionally, children with more frequent enuretic episodes demonstrated a trend of lower ADH levels ( < 0.05).
This study provides evidence of a significant association between decreased diurnal serum ADH levels and PNE in children. These findings contribute to a better understanding of the pathophysiology of PNE and suggest potential avenues for novel treatment strategies, emphasizing the importance of evaluating ADH levels in PNE management.
原发性夜间遗尿症（PNE）是一种常见的儿科疾病，其特征为夜间不自主尿床。原发性单纯性夜间遗尿症（PMNE）与抗利尿激素（ADH）分泌改变有关，且无下尿路症状。本研究旨在比较PMNE患儿与对照组的血清ADH水平，以探讨其在PMNE病理生理学中的潜在作用。
本横断面研究纳入了2022年1月至2023年7月期间在国家肾脏疾病和泌尿外科研究所（NIKDU）儿科肾病门诊就诊的40名6至15岁的PMNE患儿以及40名年龄匹配的无遗尿症儿童（对照组）。采集血样及其他临床信息并进行实验室检查，以确保符合纳入和排除标准。采用精氨酸加压素ELISA试剂盒通过竞争性免疫测定法检测空腹血清ADH水平。使用学生t检验分析连续变量的相关临床和人口统计学数据，使用卡方检验或Fisher精确检验分析分类变量。
PMNE组参与者的平均年龄为8.82±2.71岁，对照组为9.01±2.54岁（P = 0.760）。性别与PMNE之间无显著关联（P = 0.370）。与对照组相比，PMNE患儿的血清ADH水平显著降低（P < 0.05）。此外，遗尿发作频率较高的患儿ADH水平有降低趋势（P < 0.05）。
本研究提供了儿童日间血清ADH水平降低与PNE之间存在显著关联的证据。这些发现有助于更好地理解PNE的病理生理学，并为新的治疗策略提供潜在途径，强调了在PNE管理中评估ADH水平的重要性。
