Suzuki K, Kobayashi M, Ito A, Nakgawa M
Cornell Vet. 1985 Apr;75(2):348-65.
A total of 39 Holstein cattle were grazed in tracts of wild grassland on account of shortage in pasture grass. Twenty-nine cattle were affected and 26 of them died during a 21-day period. The main signs were depression, anorexia, ascites, and oliguria. There was elevated serum urea nitrogen and sugar and protein in the urine. Pathological examination revealed turbid swelling of the kidney, an increase in the amount of fluid in the body cavity, edema in the perirenal adipose tissue and hemorrhage in various visceral organs and tissues. Histologically, acute tubular necrosis in the kidney, hypoplasia of the erythroblast series in the bone marrow, atrophy and degeneration of the lymphatic tissue and focal necrosis of the liver were observed in many of the cattle. Among cows experimentally fed Narthecium asiaticum Maxim., Polygonum sachalinense Fr. Schum., and Vitis coignetiae Pulliat which were presumed to have been ingested in large amounts by grazing cattle in the field, the cows fed N. asiaticum revealed the clinical, biochemical and pathological changes similar to those noticed in naturally affected cattle. Cows fed P. sachalinense and V. coignetiae showed no distinct systemic symptoms except transient anorexia and hypothermia.
由于牧场草短缺，共有39头荷斯坦奶牛在野生草地上放牧。在21天内，29头牛受到影响，其中26头死亡。主要症状为精神沉郁、厌食、腹水和少尿。血清尿素氮升高，尿中糖和蛋白质含量增加。病理检查显示肾脏浊肿，体腔积液增多，肾周脂肪组织水肿，各内脏器官和组织出血。组织学检查发现，许多牛出现肾脏急性肾小管坏死、骨髓红细胞系发育不全、淋巴组织萎缩和变性以及肝脏局灶性坏死。在实验性喂食亚洲藜芦、库页蓼和山葡萄的奶牛中，据推测野外放牧的牛大量摄入了这些植物，喂食亚洲藜芦的奶牛出现了与自然发病牛相似的临床、生化和病理变化。喂食库页蓼和山葡萄的奶牛除了短暂的厌食和体温过低外，没有明显的全身症状。
