Hanosh Swithin, K Monisha, George Sajan D
Department of Atomic and Molecular Physics, Manipal Academy of Higher Education, Manipal 576104, India.
Centre for Applied Nanosciences (CANs), Manipal Academy of Higher Education, Manipal 576104, India.
Anal Chem. 2025 Feb 11;97(5):2610-2617. doi: 10.1021/acs.analchem.4c01844. Epub 2025 Jan 28.
Slippery liquid-infused porous surfaces (SLIPSs) are a class of surface that offers low contact angle hysteresis and low tilt angle for water droplet shedding. This property also endows the surface with pinning-free evaporation, which in turn has been exploited for analyte concentration enrichment for Surface Enhanced Raman Spectroscopic applications and antibiofouling. Herein, we demonstrate a facile approach for creating SLIPS with low contact angle hysteresis and low tilt angle for water shedding by coating the equal-volume mixture of polydimethylsiloxane (PDMS) and silicone oil. By exploiting the in situ plasmonic particle reduction capability of the PDMS, the surface is converted to plasmonic SLIPS, which illustrates its potential as a sensitive analytical platform via surface-enhanced Raman spectroscopy. The Raman spectroscopic studies using crystal violet as a reference sample show a limit of detection of 76 pM. Further, we have demonstrated that the fabricated plasmonic substrate is found to be more efficient in inhibiting proteins (bovine serum albumin) on the surface compared to pristine PDMS surfaces. Our fabricated plasmonic surface can find applications in ultrasensitive molecular detection for applications related to analytical chemistry, diagnostics, environmental monitoring, and national security and more importantly can control the nonspecific adsorption of proteins.
注入滑液的多孔表面（SLIPSs）是一类具有低接触角滞后和低倾斜角以实现水滴脱落的表面。这种特性还赋予该表面无钉扎蒸发能力，进而已被用于表面增强拉曼光谱应用中的分析物浓缩富集以及抗生物污染。在此，我们展示了一种简便的方法，通过涂覆聚二甲基硅氧烷（PDMS）和硅油的等体积混合物来制备具有低接触角滞后和低倾斜角以实现水脱落的SLIPS。通过利用PDMS的原位等离子体粒子还原能力，该表面被转化为等离子体SLIPS，这表明其作为通过表面增强拉曼光谱的灵敏分析平台的潜力。以结晶紫作为参考样品的拉曼光谱研究显示检测限为76 pM。此外，我们已证明，与原始PDMS表面相比，所制备的等离子体基底在抑制表面蛋白质（牛血清白蛋白）方面更有效。我们制备的等离子体表面可用于与分析化学、诊断、环境监测和国家安全相关的超灵敏分子检测应用，更重要的是可以控制蛋白质的非特异性吸附。
