Department of Chemistry, Department of Chemical Engineering, Department of Materials Science & Engineering, and ‡Laboratory for Synthetic-Biologic Interactions, Texas A&M University , College Station, Texas 77842-3012, United States.
ACS Appl Mater Interfaces. 2014;6(21):19265-74. doi: 10.1021/am505296n. Epub 2014 Oct 20.
Synthesis of terpolymer coatings composed of hyperbranched fluoropolymers cross-linked with bisamino-propyl poly(ethylene glycol) and bisamino-propyl polydimethylsiloxane (PDMS) was performed to generate antibiofouling surfaces. Nanoscale imaging and surface spectroscopy confirmed that this system possessed complex surface topographies and chemical compositions. Surface complexity was determined to be due to molecular interactions, phase segregation, and compositional gradients arising between the three components. A clear difference in surface behavior was observable before and after exposure to water. Antibiofouling characteristics were investigated by bovine serum albumin (BSA) adsorption studies; the terpolymer coating displayed a 60% greater resistance to protein adsorption in comparison to the fouling of a commercial antibiofouling silicone coating. The unique surface topography, topology, and chemical heterogeneity expressed at a variety of scales provide a robust regime for the generation of hardy, complex surfaces known to incorporate characteristics appropriate for antibiofouling applications. Thorough assessment of thermal responses and mechanical properties in relevant environments demonstrated a formulation platform immediately appropriate for consideration in marine and in vivo applications.
合成了由超支化氟聚合物与双氨基丙基聚（乙二醇）和双氨基丙基聚二甲基硅氧烷（PDMS）交联而成的三元共聚物涂层，以生成抗生物污染表面。纳米级成像和表面光谱证实，该系统具有复杂的表面形貌和化学成分。表面复杂性归因于三种成分之间的分子相互作用、相分离和组成梯度。在暴露于水前后，可观察到表面行为的明显差异。通过牛血清白蛋白（BSA）吸附研究来研究抗生物污染特性；与商业抗生物污染硅酮涂层的污染相比，三元共聚物涂层对蛋白质吸附的抵抗力提高了 60%。在各种尺度上表现出的独特表面形貌、拓扑和化学不均匀性为生成坚固、复杂的表面提供了一个强大的体系，这些表面具有适合抗生物污染应用的特性。在相关环境中对热响应和机械性能进行了全面评估，证明了一种配方平台非常适合在海洋和体内应用中考虑。
