影响范围：筛选……中必需蛋白激酶的挑战
mSphere of Influence: The challenge of screening for essential protein kinases in .
作者信息
Chiurillo Miguel A
机构信息
Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
出版信息
mSphere. 2025 Feb 25;10(2):e0059824. doi: 10.1128/msphere.00598-24. Epub 2025 Jan 28.
Abstract
Miguel Chiurillo works in the field of protein kinases, studying their role in cell signaling and cell cycle progression in . In this mSphere of Influence article, he reflects on how the research articles "Systematic functional analysis of protein kinases identifies regulators of differentiation or survival" by Baker et al. and "Screening the kinome with high throughput tagging identifies a regulator of invasion and egress" by Smith et al. made an impact on his understanding of the complexity of the kinome and the challenges to unravel it.
摘要
米格尔·丘里洛从事蛋白激酶领域的研究，探讨它们在细胞信号传导和细胞周期进程中的作用。在这篇“影响范围”文章中，他反思了贝克等人所著的“蛋白激酶的系统功能分析确定分化或存活的调节因子”以及史密斯等人所著的“通过高通量标记筛选激酶组确定侵袭和逸出的调节因子”这两篇研究论文如何影响了他对激酶组复杂性及其解析挑战的理解。
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