Wierzba Karol, Chmielewski Michał, Błeszyńska-Marunowska Emilia, Jagiełło Kacper, Wierucki Łukasz, Zdrojewski Tomasz
Department of Rheumatology, Clinical Immunology, Geriatrics and Internal Medicine Medical, University of Gdansk, Smoluchowskiego 17, 80-214, Gdańsk, Poland.
Department of Occupational, Metabolic and Internal Diseases, Medical University of Gdansk, Gdańsk, Poland.
Drugs Aging. 2025 Mar;42(3):245-255. doi: 10.1007/s40266-025-01180-x. Epub 2025 Jan 28.
Older adults represent a growing proportion of the general population. Nonsteroidal anti-inflammatory drugs (NSAIDs) constitute a group of medicines that are both necessary, owing to their anti-inflammatory, analgesic, and cardioprotective abilities, and potentially harmful, owing to their side effects.
This study provides a comprehensive analysis of NSAID usage patterns among Polish adults aged 60 years and older. It focused on the regular use (≥ three times per week) of two types of NSAIDs: acetylsalicylic acid (ASA) and non-ASA NSAIDs, examining consumption on the basis of age, sex, educational level, and place of residence.
Data were collected from the PolSenior2 study, a national cross-sectional survey of 5987 Polish individuals aged 60-106 years, conducted from 2018 to 2019.
The study found that 30.7% [95% confidence interval (CI) 28.8-32.7)]of Polish seniors regularly used NSAIDs, with 26.2% (95% CI 24.5-28.0) regularly using ASA, 6.3% (95% CI 5.3-7.2) regularly using non-ASA NSAIDs, and 1.9% (95% CI 1.4-2.3) reporting regular use of both. An age-related increase in regular NSAID use, including ASA, was observed. Women were more likely than men to use non-ASA NSAIDs regularly, whereas men in the 70-79 age group were more likely to use ASA. A lower level of education was associated with more frequent NSAID use.
The findings have implications for healthcare practitioners and policymakers, emphasizing the need for careful management of NSAID use. The study contributes to a more nuanced understanding of NSAID usage and underscores the necessity for tailored healthcare strategies to ensure safe and effective medication use among older adults.
老年人在总人口中所占比例日益增加。非甾体抗炎药(NSAIDs)是一类药物,因其具有抗炎、止痛和心脏保护能力而不可或缺,但同时因其副作用又具有潜在危害。
本研究对60岁及以上波兰成年人使用非甾体抗炎药的模式进行了全面分析。研究重点关注两种非甾体抗炎药的常规使用(每周≥三次):乙酰水杨酸(ASA)和非ASA类非甾体抗炎药,同时根据年龄、性别、教育程度和居住地点对用药情况进行了考察。
数据收集自PolSenior2研究,这是一项在2018年至2019年期间对5987名年龄在60 - 106岁的波兰人进行的全国性横断面调查。
研究发现,30.7%[95%置信区间(CI)28.8 - 32.7]的波兰老年人经常使用非甾体抗炎药,其中26.2%(95%CI 24.5 - 28.0)经常使用ASA,6.3%(95%CI 5.3 - 7.2)经常使用非ASA类非甾体抗炎药,1.9%(95%CI 1.4 - 2.3)报告同时经常使用这两种药物。观察到包括ASA在内的非甾体抗炎药常规使用呈现与年龄相关的增加趋势。女性比男性更有可能经常使用非ASA类非甾体抗炎药,而70 - 79岁年龄组的男性更有可能使用ASA。教育程度较低与更频繁使用非甾体抗炎药有关。
这些发现对医疗从业者和政策制定者具有启示意义,强调了谨慎管理非甾体抗炎药使用的必要性。该研究有助于更细致地了解非甾体抗炎药的使用情况,并强调需要制定针对性的医疗保健策略,以确保老年人安全有效地用药。