Oxidative Scission of Bicyclo[2.2.2]octenones: Untying the α-Dimethoxycarbonyl.

This study explores the selective oxidative scission of bicyclo[2.2.2]octenones derived from masked -benzoquinones (MOBs). By employing the fragmentation of ketoximes and Schmidt-type reactions, we achieved the cleavage of α-dimethoxy carbonyl groups to yield highly functionalized cyclohexene frameworks, showcasing the expanding synthetic utility of bicyclo[2.2.2]octenones in complex organic synthesis. The methodologies developed are anticipated to contribute to advancements in organic and pharmaceutical chemistry.