Sidhu G S, Narasimharao K L, Usha Rani V, Sarkar A K, Mitra S K
Dig Dis Sci. 1985 May;30(5):483-8. doi: 10.1007/BF01318183.
An experimental model of massive (80%) small bowel resection and antiperistaltic colon interposition in between the remnant jejunum and ileum was created in rhesus monkeys. The gastrointestinal functions were assessed preoperatively and at different periods after the operation. Progressive increase in the transit time and enhanced absorption of D-xylose and vitamin B12 was observed in these animals. The transit time marginally increased till three months postoperatively, and a significant increase was observed later (4-12 months) in the colon autografted monkeys. After three months, the D-xylose absorption in the colon interpositioned animals was nearly equal to that of normal monkeys. There was no significant difference in the vitamin B12 absorption in the normal and operated animals up to three months, but a significant rise was observed in the latter group after this period. The fecal fat excretion was 33-44% initially, and it gradually decreased to near normal values after nine months. The antiperistaltic colon interposition was effective in improving the early postoperative survival in animals after massive small bowel resection and enhanced the bowel absorption considerably.
在恒河猴身上建立了一个实验模型，即进行80%的小肠大部切除，并在残留的空肠和回肠之间置入逆蠕动的结肠。在术前以及术后不同时期对胃肠功能进行评估。观察到这些动物的转运时间逐渐增加，并且D-木糖和维生素B12的吸收增强。在结肠自体移植的猴子中，转运时间在术后三个月内略有增加，之后（4至12个月）出现显著增加。三个月后，置入结肠的动物中D-木糖的吸收几乎与正常猴子相等。在三个月内，正常动物和手术动物的维生素B12吸收没有显著差异，但在此之后，后一组出现了显著上升。粪便脂肪排泄最初为33%-44%，九个月后逐渐降至接近正常水平。逆蠕动结肠置入有效地提高了小肠大部切除术后动物的早期存活率，并显著增强了肠道吸收。
