Lv Xuejiao, Wang Wenrui, Dong Hongna, Li Wei
Department of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, Jilin, China.
Department of Hepatopancreatobiliary Medicine, Digestive Diseases Center, The Second Hospital of Jilin University, Changchun, Jilin, China.
Int Immunopharmacol. 2025 Feb 20;148:114143. doi: 10.1016/j.intimp.2025.114143. Epub 2025 Jan 27.
Asthma is a heterogeneous disease characterized by chronic airway inflammation and hyperresponsiveness. A number of immune cells are involved in asthma pathogenesis, such as eosinophils, mast cells, T lymphocytes and neutrophils, as well as airway epithelial cells. Glycolysis plays a crucial role in glucose metabolism, and serves as a bridge between metabolic and inflammatory dysfunction. Research has found that abnormal glycolytic metabolism in various immune cells may contribute to the pathogenesis of asthma by inducing dysregulation in congenital and adaptive immune responses. Therefore, the inhibition of glycolysis can be a viable approach to prevent airway inflammation in asthma. The present study reviews the relationship between glycolysis and inflammatory cells in different asthma subtypes, and its potential therapeutic significance.
哮喘是一种以慢性气道炎症和高反应性为特征的异质性疾病。多种免疫细胞参与哮喘的发病机制，如嗜酸性粒细胞、肥大细胞、T淋巴细胞和中性粒细胞，以及气道上皮细胞。糖酵解在葡萄糖代谢中起关键作用，并作为代谢功能障碍和炎症功能障碍之间的桥梁。研究发现，各种免疫细胞中异常的糖酵解代谢可能通过诱导先天性和适应性免疫反应失调而导致哮喘的发病机制。因此，抑制糖酵解可能是预防哮喘气道炎症的一种可行方法。本研究综述了不同哮喘亚型中糖酵解与炎症细胞之间的关系及其潜在的治疗意义。
