Subramani Tarunkarthick, Saravanan Harish, David Helma, Solanke Jayshree, Rajaramon Shobana, Dandela Rambabu, Solomon Adline Princy
Quorum Sensing Laboratory, Centre for Research in Infectious Diseases (CRID), School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur 613401, India.
Department of Industrial and Engineering Chemistry, Institute of Chemical Technology, Bhubaneswar, Odisha, India.
Bioorg Chem. 2025 Mar;156:108192. doi: 10.1016/j.bioorg.2025.108192. Epub 2025 Jan 23.
Recent research has shed light on the complex world of bacterial communication through quorum sensing. This sophisticated intercellular signalling mechanism, driven by auto-inducers, regulates crucial bacterial community behaviours such as biofilm formation, expression of virulence factors, and resistance mechanisms. The increasing threat of antibiotic resistance, coupled with quorum sensing mediated response, necessitates alternative strategies to combat bacterial infections. Quorum quenching has emerged as a promising approach, utilizing quorum quenching enzymes and quorum sensing inhibitors to disrupt quorum sensing signalling pathways, thus reducing virulence and biofilm formation. This review focuses on natural and synthetic bioorganic compounds that act as quorum-sensing inhibitors, providing insights into their mechanisms, structure-activity relationships, and potential as anti-virulence agents. The review also explores the communication languages of bacteria, including AHLs in gram-negative bacteria, oligopeptides in gram-positive bacteria, and LuxS, a universal microbial language. By highlighting recent advancements and prospects in bioorganic QSIs, this article underscores their crucial role in developing effective anti-virulence therapies and combating the growing threat of antimicrobial resistance.
最近的研究揭示了细菌通过群体感应进行交流的复杂世界。这种由自诱导物驱动的复杂细胞间信号传导机制，调控着诸如生物膜形成、毒力因子表达和耐药机制等关键的细菌群体行为。抗生素耐药性的威胁不断增加，再加上群体感应介导的反应，使得对抗细菌感染需要替代策略。群体猝灭已成为一种有前景的方法，利用群体猝灭酶和群体感应抑制剂来破坏群体感应信号通路，从而降低毒力和生物膜形成。这篇综述聚焦于作为群体感应抑制剂的天然和合成生物有机化合物，深入探讨它们的作用机制、构效关系以及作为抗毒力剂的潜力。该综述还探索了细菌的交流语言，包括革兰氏阴性菌中的AHLs、革兰氏阳性菌中的寡肽以及一种通用的微生物语言LuxS。通过强调生物有机群体感应抑制剂的最新进展和前景，本文强调了它们在开发有效的抗毒力疗法以及应对日益增长的抗菌耐药性威胁方面的关键作用。
