Sluiter H E, Huysmans F T, Thien T A, Koene R A
Drugs. 1985;29 Suppl 2:144-53. doi: 10.2165/00003495-198500292-00025.
The effects of intravenous administration of a new calcium antagonist, felodipine, were studied in healthy subjects and hypertensive patients. Felodipine infused at a rate of 0.01 mg/min in 10 normotensive volunteers caused gradual haemodynamic and hormonal changes compatible with a direct vasodilatory mechanism of action; it also had a diuretic and natriuretic effect. When infused at a mean dose of 0.02 mg/kg bodyweight over 20 to 120 minutes in 7 patients with a hypertensive emergency, felodipine caused a rapid reduction in blood pressure with a maximal fall in mean arterial pressure of 30.4 +/- 7.3% (mean +/- 1 SD) in 30 minutes. No serious side effects were observed. The haemodynamic effectiveness of an infusion rate of 0.01 mg/min was confirmed in a pilot study of 5 patients with refractory hypertension. On the basis of these findings, a schedule for the treatment of acute hypertension with intravenous felodipine is proposed.
在健康受试者和高血压患者中研究了新型钙拮抗剂非洛地平静脉给药的效果。以0.01mg/min的速率给10名血压正常的志愿者输注非洛地平，可引起与直接血管舒张作用机制相符的逐渐的血流动力学和激素变化；它还具有利尿和排钠作用。在7例高血压急症患者中，以0.02mg/kg体重的平均剂量在20至120分钟内输注非洛地平，可使血压迅速降低，30分钟内平均动脉压最大降幅为30.4±7.3%（平均值±1标准差）。未观察到严重副作用。在一项针对5例顽固性高血压患者的初步研究中证实了0.01mg/min输注速率的血流动力学有效性。基于这些发现，提出了静脉注射非洛地平治疗急性高血压的方案。
