Muir A L, Wathen C G, Hannan W J
Drugs. 1985;29 Suppl 2:59-65. doi: 10.2165/00003495-198500292-00012.
The acute cardiovascular effects of oral felodipine (0.05 mg/kg and 0.1 mg/kg) were studied using radionuclide methods in 14 hypertensive patients. Eight were previously untreated and 6 had been treated with atenolol 100mg daily for a least 1 month. The maximal effects were observed 60 minutes after the first oral dose and no greater effect was observed with the higher dose. Felodipine caused a reduction in systemic vascular resistance, with a fall in blood pressure and an increase in cardiac output and left ventricular ejection fraction. Those responses were presumably mediated by the reduction in afterload, as they were not modified by pretreatment with atenolol. There were no changes in venous capacitance and the overall pattern of response was similar to that noted with hydralazine. Thus, in hypertensive subjects felodipine acts as a potent arteriolar vasodilator. The results suggest the drug may be an effective means of controlling hypertension, particularly when given in combination with other antihypertensive therapy.
采用放射性核素方法，在14例高血压患者中研究了口服非洛地平（0.05mg/kg和0.1mg/kg）的急性心血管效应。其中8例患者此前未接受过治疗，6例患者曾每日服用100mg阿替洛尔至少1个月。首次口服给药后60分钟观察到最大效应，较高剂量未观察到更大效应。非洛地平导致全身血管阻力降低，血压下降，心输出量和左心室射血分数增加。这些反应可能是由后负荷降低介导的，因为阿替洛尔预处理并未改变这些反应。静脉容量无变化，总体反应模式与肼屈嗪相似。因此，在高血压患者中，非洛地平是一种有效的小动脉血管扩张剂。结果表明，该药物可能是控制高血压的有效手段，尤其是与其他抗高血压疗法联合使用时。
