Jung Joon Min, Kim Do Hyung, Kim Ye-Jee, Moon Ik Jun, Lee Woo Jin, Chang Sung Eun, Lee Mi Woo, Won Chong Hyun
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.
Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Sci Rep. 2025 Jan 28;15(1):3541. doi: 10.1038/s41598-025-87838-3.
There is limited data on the risk of second primary malignancies (SPMs) in Asian melanoma survivors. This study aimed to identify the risk of SPMs in Asian melanoma survivors. Standardized incidence ratios (SIRs) were calculated for overall and specific SPMs. The risk factor for overall SPM development was analyzed using a multivariable Cox regression model. A total of 10,070 patients with melanoma were included in the study. Melanoma survivors exhibited an increased risk of overall SPM (SIR, 1.51; 95% confidence interval [CI], 1.34-1.70). Additionally, specific SPMs were more common among melanoma survivors, including nonmelanoma skin cancer, oral cavity and pharyngeal cancer, renal cancer, female breast cancer, lung cancer, pancreatic cancer, and liver cancer. Independent risk factors for overall SPM development included a Charlson Comorbidity Index ≥ 1 (adjusted hazard ratio [aHR], 1.41; 95% CI, 1.07-1.87), and a body mass index ≥ 25 kg/m (aHR, 1.47; 95% CI, 1.04-2.08). Inherent uncertainty related to diagnostic codes may exist. The risk of overall and specific SPMs was significantly elevated in Asian melanoma survivors, particularly among those with invasive melanoma. Among modifiable factors, a high body mass index (BMI) was associated with an increased risk of SPM.
关于亚洲黑色素瘤幸存者发生第二原发性恶性肿瘤（SPM）风险的数据有限。本研究旨在确定亚洲黑色素瘤幸存者发生SPM的风险。计算了总体和特定SPM的标准化发病比（SIR）。使用多变量Cox回归模型分析了总体SPM发生的危险因素。该研究共纳入10,070例黑色素瘤患者。黑色素瘤幸存者发生总体SPM的风险增加（SIR，1.51；95%置信区间[CI]，1.34 - 1.70）。此外，特定的SPM在黑色素瘤幸存者中更为常见，包括非黑色素瘤皮肤癌、口腔和咽喉癌、肾癌、女性乳腺癌、肺癌、胰腺癌和肝癌。总体SPM发生的独立危险因素包括Charlson合并症指数≥1（调整后风险比[aHR]，1.41；95%CI，1.07 - 1.87），以及体重指数≥25 kg/m²（aHR，1.47；95%CI，1.04 - 2.08）。可能存在与诊断编码相关的固有不确定性。亚洲黑色素瘤幸存者发生总体和特定SPM的风险显著升高，尤其是侵袭性黑色素瘤患者。在可改变的因素中，高体重指数（BMI）与SPM风险增加相关。
