Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea.
Cancer Res Treat. 2022 Jul;54(3):937-949. doi: 10.4143/crt.2021.871. Epub 2021 Sep 30.
Melanoma incidence is rising worldwide along with the associated personal and socioeconomic health expenditures. We investigated the incidence and survival-rate patterns of melanoma in South Korea using nationwide data.
This retrospective cohort study included patients with melanoma between 2004 and 2017, based on National Health Insurance (NHI) claims data in South Korea. The incidence, prevalence, and survival rate were analyzed along with baseline demographic characteristics. We collected solar irradiation dose (SID) and healthcare ranking score (HRS) according to the administrative district from the Korea Meteorological Administration and Korea Health Promotion Institute. The incidence and survival rates were assessed using Pearson's correlation, the Kaplan-Meier estimation, multiple linear regression, and multiple logistic regression methods.
Twenty-five thousand, five hundred ninety-one patients with melanoma were diagnosed during the study period. The age-standardized incidence of melanoma steadily increased from 2004 to 2017 from 2.6 to 3.0/100,000/yr. The incidence of melanoma increased with significantly higher income (p < 0.05). The prevalence followed a similar pattern as the incidence. According to multivariate analysis, HRS significantly influenced the incidence of melanoma in high sun-exposed sites (p < 0.001). There was no significant change in annual mortality. Women had a higher 5-year survival rate than men (78.4% vs. 72.8%). Mortality by the administrative district was highly correlated with HRS.
The incidence of melanoma is increasing in South Korea. A low HRS is associated with both higher incidence and mortality. The findings of this study could be utilized as a guideline for treating melanoma patients.
随着与黑色素瘤相关的个人和社会经济健康支出的增加，黑色素瘤的发病率在全球范围内呈上升趋势。我们使用全国范围内的数据调查了韩国黑色素瘤的发病率和生存率模式。
本回顾性队列研究基于韩国国家健康保险（NHI）理赔数据，纳入了 2004 年至 2017 年间患有黑色素瘤的患者。分析了发病率、患病率和生存率以及基线人口统计学特征。我们根据行政区域从韩国气象局和韩国健康促进研究所收集了太阳辐射剂量（SID）和保健排名评分（HRS）。使用 Pearson 相关、Kaplan-Meier 估计、多元线性回归和多元逻辑回归方法评估发病率和生存率。
在研究期间，诊断出 25591 例黑色素瘤患者。2004 年至 2017 年，年龄标准化黑色素瘤发病率从 2.6/100,000/yr 稳步上升至 3.0/100,000/yr。发病率与较高的收入显著相关（p<0.05）。患病率也呈现出与发病率相似的模式。根据多变量分析，HRS 显著影响高阳光暴露部位黑色素瘤的发病率（p<0.001）。年死亡率没有明显变化。女性的 5 年生存率高于男性（78.4%比 72.8%）。各行政区的死亡率与 HRS 高度相关。
韩国黑色素瘤的发病率正在上升。HRS 较低与发病率和死亡率的升高均相关。本研究的结果可作为治疗黑色素瘤患者的指南。
