Sakir Mohammad, Ballal Sanjana, Rastogi Sameer, Yadav Madhav Prasad, Roesch Frank, Chandekar Kunal, Gb Priyanka, Tripathi Madhavi, Dhiman Ayan, Taggar Mehul, Martin Marcel, Bal Chandrasekhar
Departments of Nuclear Medicine.
Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.
Clin Nucl Med. 2025 May 1;50(5):e271-e279. doi: 10.1097/RLU.0000000000005697. Epub 2025 Jan 29.
This study aimed to compare the diagnostic efficacy of [ 68 Ga]Ga-DOTA.SA.FAPi and [ 18 F]F-FDG PET/CT for detecting primary and metastatic lesions in sarcoma patients.
The analysis included both patient-based and lesion-based comparisons of PET/CT scans in individuals with histologically confirmed sarcoma.
A total of 23 sarcoma patients (mean age 43.0 ± 16.5 years; range: 21-76 years) underwent both [ 18 F]F-FDG and [ 68 Ga]Ga-DOTA.SA.FAPi PET/CT scans. Histological distribution included 30% synovial sarcoma, 13% liposarcoma, and 21.7% leiomyosarcoma, with 70% of patients presenting with distant metastases. Detection rates for primary tumors were similar between [ 68 Ga]Ga-DOTA.SA.FAPi and [ 18 F]F-FDG PET/CT (85.7% vs 100%, P = 0.149). Lymph node detection rates were also comparable (80% vs 100%, P = 0.146). Lesion-based analysis revealed that [ 68 Ga]Ga-DOTA.SA.FAPi detected 220 lesions (83% efficiency) compared with 249 lesions (94% efficiency) for [ 18 F]F-FDG ( P < 0.0001). Notably, [ 68 Ga]Ga-DOTA.SA.FAPi demonstrated superior detection of liver (54 vs 38 lesions, P < 0.0001) and bone metastases (125 vs 102 lesions, P < 0.0001).
Our study shows that although [ 18 F]F-FDG PET/CT offers superior overall lesion detection efficiency, [ 68 Ga]Ga-DOTA.SA.FAPi PET/CT excels in identifying specific metastatic sites, particularly in bone and liver. These findings highlight the complementary roles of both imaging modalities in sarcoma evaluation.
本研究旨在比较[68Ga]Ga-DOTA.SA.FAPi和[18F]F-FDG PET/CT在检测肉瘤患者原发灶和转移灶方面的诊断效能。
分析包括对组织学确诊的肉瘤患者进行基于患者和基于病灶的PET/CT扫描比较。
共有23例肉瘤患者（平均年龄43.0±16.5岁；范围：21 - 76岁）接受了[18F]F-FDG和[68Ga]Ga-DOTA.SA.FAPi PET/CT扫描。组织学分布包括30%滑膜肉瘤、13%脂肪肉瘤和21.7%平滑肌肉瘤，70%的患者有远处转移。[68Ga]Ga-DOTA.SA.FAPi和[18F]F-FDG PET/CT对原发肿瘤的检出率相似（85.7%对100%，P = 0.149）。淋巴结检出率也相当（80%对100%，P = 0.146）。基于病灶的分析显示，[68Ga]Ga-DOTA.SA.FAPi检测到220个病灶（效率83%）而[18F]F-FDG检测到249个病灶（效率94%）（P < 0.0001）。值得注意的是，[68Ga]Ga-DOTA.SA.FAPi在检测肝转移（54个病灶对38个病灶，P < 0.0001）和骨转移（125个病灶对102个病灶，P < 0.0001）方面表现更优。
我们的研究表明，虽然[18F]F-FDG PET/CT在整体病灶检测效率上更优，但[68Ga]Ga-DOTA.SA.FAPi PET/CT在识别特定转移部位方面表现出色，尤其是在骨和肝。这些发现凸显了两种成像方式在肉瘤评估中的互补作用。
