Groenset Charlotte, Bech Magnus N, Jarden Mary, Høgdal Nina, Hutchings Martin, Suetta Charlotte, Christensen Jan
Department of Occupational Therapy and Physiotherapy, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Department of Hematology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health, University of Copenhagen, Copenhagen, Denmark.
Acta Oncol. 2025 Jan 28;64:129-142. doi: 10.2340/1651-226X.2025.42056.
This study aims to identify and summarize evidence on the effectiveness of exercise-based interventions on muscle mass, muscle strength, functional performance, aerobic capacity, health-related quality of life (HRQoL), feasibility of the interventions, in patients with malignant lymphoma undergoing chemotherapy.
A systematic search was conducted in six electronic databases and trials registers on November 15, 2023. Peer-reviewed randomized controlled trials (RCTs) comparing exercise intervention with controls/usual care in adults (≥18 years) diagnosed with Hodgkin's lymphoma and non-Hodgkin's lymphoma undergoing chemotherapy were considered for inclusion. All study authors were contacted to obtain unpublished subgroup data. Two reviewers independently screened and extracted data and assessed the quality of evidence using the revised Cochrane risk-of-bias tool for randomized trials.
Six RCTs published between 2009 and 2021, with 838 participants, were included. Due to clinical heterogeneity, a meta-analysis was not feasible, therefore the results were synthesized narratively. Exercise interventions during treatment were found to be feasible with few adverse events reported. The included studies indicate positive effects of exercise during chemotherapy on muscle mass, muscle strength, functional performance, aerobic capacity, and HRQoL compared to usual care.
Despite extensive search criteria, a limited number of heterogenous studies were eligible, which may explain the very low certainty of evidence for all outcomes. Nonetheless, exercise-based interventions conducted during treatment were feasible, safe and potentially effective. Further studies are needed to guide future exercise recommendations for these patients.
本研究旨在识别和总结基于运动的干预措施对接受化疗的恶性淋巴瘤患者的肌肉质量、肌肉力量、功能表现、有氧运动能力、健康相关生活质量（HRQoL）以及干预措施可行性的有效性证据。
于2023年11月15日在六个电子数据库和试验注册库中进行了系统检索。纳入了比较运动干预与对照组/常规护理的同行评审随机对照试验（RCT），这些试验的受试者为年龄≥18岁、被诊断为霍奇金淋巴瘤和非霍奇金淋巴瘤且正在接受化疗的成年人。联系了所有研究作者以获取未发表的亚组数据。两名评审员独立筛选和提取数据，并使用修订后的Cochrane随机试验偏倚风险工具评估证据质量。
纳入了2009年至2021年间发表的6项RCT，共838名参与者。由于临床异质性，无法进行荟萃分析，因此对结果进行了叙述性综合。发现治疗期间的运动干预是可行的，报告的不良事件较少。纳入的研究表明，与常规护理相比，化疗期间运动对肌肉质量、肌肉力量、功能表现、有氧运动能力和HRQoL有积极影响。
尽管检索标准广泛，但符合条件的异质性研究数量有限，这可能解释了所有结局证据的确定性非常低的原因。尽管如此，治疗期间进行的基于运动的干预措施是可行、安全且可能有效的。需要进一步的研究来指导未来针对这些患者的运动建议。
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