Department of Rehabilitation Medicine, The Royal Melbourne Hospital, 34-54 Poplar Road Parkville, Victoria, Australia. E-mail:
J Rehabil Med. 2021 Mar 17;53(3):jrm00163. doi: 10.2340/16501977-2810.
To evaluate existing evidence from published systematic reviews for the effectiveness of rehabilitation interventions in patients with lymphoma.
A comprehensive literature search was conducted using medical/health science databases up to 1 October 2020. Bibliographies of pertinent articles, journals and grey literature were searched.
Two reviewers independently selected and reviewed potential reviews for methodological quality and graded the quality of evidence for outcomes using validated tools. Any discrepancies were resolved by final group consensus.
Twelve systematic reviews (n = 101 studies, 87,132 patients with lymphoma) evaluated 3 broad categories of rehabilitation interventions (physical modalities, nutrition and complementary medicine). Most reviews were of moderate-to-low methodological quality. The findings suggest: moderate-quality evidence for exercise programmes for improved fatigue and sleep disturbance; low-quality evidence for exercise therapy alone and qigong/tai chi for improved symptoms and overall quality of life, and an inverse association between sunlight/ultraviolet radiation exposure and incidence of non-Hodgkin's lymphoma; and very low-quality evidence for beneficial effects of yoga for sleep disturbances. Association between physical activity and lymphoma risk is indistinct.
Despite a range of rehabilitation modalities used for patients with lymphoma, high-quality evidence for many is sparse. Beneficial effects of exercise programmes were noted for fatigue, psychological symptoms and quality of life. More research with robust study design is required to determine the effective rehabilitation approaches.
评估已发表的系统评价中关于淋巴瘤患者康复干预措施有效性的现有证据。
截至 2020 年 10 月 1 日，我们使用医学/健康科学数据库进行了全面的文献检索。还检索了相关文章、期刊和灰色文献的参考文献。
两位评审员独立选择和评价了潜在的综述的方法学质量，并使用经过验证的工具对结局的证据质量进行分级。任何分歧均通过最终小组共识解决。
12 项系统评价（n=101 项研究，87132 例淋巴瘤患者）评估了 3 种广泛的康复干预措施（物理疗法、营养和补充医学）。大多数综述的方法学质量为中低等。研究结果表明：运动方案可改善疲劳和睡眠障碍，证据质量为中等；单独运动疗法和气功/太极改善症状和整体生活质量的证据质量为低，阳光/紫外线辐射暴露与非霍奇金淋巴瘤的发病呈负相关；瑜伽对睡眠障碍有益，证据质量为极低。身体活动与淋巴瘤风险之间的关联尚不明确。
尽管针对淋巴瘤患者使用了多种康复手段，但许多方法的高质量证据仍然匮乏。运动方案对疲劳、心理症状和生活质量有有益影响。需要进行更多设计严谨的研究来确定有效的康复方法。
