Yang Xiaoran, Eckel Sandrah P, Maldonado Luis E, Yang Tingyu, Chen Xinci, Vigil Mario, Toledo-Corral Claudia M, Dunton Genevieve F, Grubbs Brendan H, Al-Marayati Laila, Lerner Deborah, Lurvey Nathana, Habre Rima, Farzan Shohreh F, Bastain Theresa M, Breton Carrie
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Department of Health Sciences, California State University, Northridge, Northridge, CA 91330, USA.
J Endocr Soc. 2025 Jan 28;9(2):bvae222. doi: 10.1210/jendso/bvae222. eCollection 2025 Jan 6.
Worldwide, obesity remains one of the most challenging crises with children being one of the most susceptible populations. The effect of maternal stress during pregnancy on newborn body composition, measured by fat mass and lean mass has, not been extensively studied.
We evaluated the association between perceived stress during late pregnancy and infant adiposity at 1 month and assessed effect modification by infant sex and preterm birth.
Mother-infant dyads (N = 138) were included from the ongoing MADRES cohort. Maternal perceived stress during late pregnancy was measured by the 10-item Perceived Stress Scale (PSS), as a cumulative score, during the third trimester. Infant adiposity measures, collected at 1 month by EchoMRI, included weight, fat mass (FM), and lean mass with FM-related ratios derived. Multivariable linear regression models with interaction terms were performed.
Most mothers reported low to moderate stress (mean ± SD PSS: 13.2 ± 5.6) during late pregnancy. A 1-SD higher PSS was associated with higher FM% (FM (g)/weight (g): β = 0.78%; 95% CI, 0.13-1.44) but we did not find significant associations for the other adiposity measures. Statistically significant effects of perceived stress on FM-related measures were observed in male infants and preterm infants (both for interaction <.05) but were null among female infants or term infants.
In this predominately low-income Hispanic population, perceived stress during late pregnancy was associated with higher FM-related body composition measures during early infancy; this association was stronger among male and preterm infants compared to the overall population and other subgroups.
在全球范围内，肥胖仍然是最具挑战性的危机之一，儿童是最易受影响的人群之一。孕期母亲压力对新生儿身体组成（通过脂肪量和去脂体重衡量）的影响尚未得到广泛研究。
我们评估了孕晚期感知压力与1个月大婴儿肥胖之间的关联，并评估了婴儿性别和早产对这种关联的影响修正作用。
从正在进行的MADRES队列中纳入母婴二元组（N = 138）。孕晚期母亲的感知压力通过10项感知压力量表（PSS）在孕晚期作为累积得分进行测量。1个月时通过EchoMRI收集的婴儿肥胖指标包括体重、脂肪量（FM）和去脂体重，并得出与FM相关的比率。进行了带有交互项的多变量线性回归模型。
大多数母亲报告在孕晚期压力为低至中度（平均±标准差PSS：13.2±5.6）。PSS每增加1个标准差与更高的FM%相关（FM（克）/体重（克）：β = 0.78%；95%置信区间，0.13 - 1.44），但我们未发现其他肥胖指标有显著关联。在男婴和早产婴儿中观察到感知压力对与FM相关指标有统计学显著影响（两者交互作用P <.05），但在女婴或足月儿中无此影响。
在这个主要为低收入西班牙裔人群中，孕晚期感知压力与婴儿早期更高的与FM相关的身体组成指标相关；与总体人群和其他亚组相比，这种关联在男婴和早产婴儿中更强。
