Jin Yan, Li Minghui, Ding Wei, Wu Huiwen
Maternal and Child Health Hospital of Hubei Province, Department of Child Health, Wuhan, Hubei Province, China.
J Med Biochem. 2024 Nov 16;43(6):960-966. doi: 10.5937/jomb0-48471.
Aim was to demonstrate the influencing factors of infant bone mineral density (BMD) and its correlation with serum 25-hydroxyvitamin D (25-(OH)D) in nursing mothers.
200 children aged 0 č 1 years were rolled into normal group (n=120) and abnormal group (n=80) regarding the results of ultrasound BMD examination. The sunshine duration of infants with different BMD and 25(OH)D, calcium and phosphorus levels of nursing mothers were analyzed, and univariate and multivariate analyses of BMD were implemented.
The results revealed that the sunshine duration and serum 25-(OH)D level of nursing mothers in abnormal group were inferior to those in normal group (P<0.05). Additionally, a notable positive correlation existed between sunshine duration, serum 25-(OH)D level of nursing mothers and BMD (r = 0.911 and 0.503, P<0.05). According to Logistic regression analysis, outdoor activity time 0 č 1 h/d, premature infants, and breastfeeding alone were independent risk factors (RFs) for abnormal BMD in infants, and vitamin D(VD) and calcium supplementation were independent protective factors (P<0.05).
VD and calcium intake, adequate sunshine duration, mixed feeding, and increasing serum 25-(OH)D can reduce the occurrence of abnormal BMD in infants.
目的是探讨哺乳期母亲中婴儿骨密度（BMD）的影响因素及其与血清25-羟基维生素D（25-(OH)D）的相关性。
根据超声骨密度检查结果，将200名0至1岁儿童分为正常组（n = 120）和异常组（n = 80）。分析不同骨密度和25(OH)D水平婴儿的日照时长，以及哺乳期母亲的钙和磷水平，并对骨密度进行单因素和多因素分析。
结果显示，异常组哺乳期母亲的日照时长和血清25-(OH)D水平低于正常组（P<0.05）。此外，哺乳期母亲的日照时长、血清25-(OH)D水平与骨密度之间存在显著正相关（r = 0.911和0.503，P<0.05）。根据Logistic回归分析，户外活动时间0至1小时/天,早产儿,以及单纯母乳喂养是婴儿骨密度异常的独立危险因素（RFs），补充维生素D（VD）和钙是独立保护因素（P<0.05）。
补充VD和钙、充足的日照时长、混合喂养以及提高血清25-(OH)D水平可降低婴儿骨密度异常的发生率。
