在接受生长激素（GH）和左甲状腺素替代治疗的雄性小鼠中，诱导生育与外周生殖参数改善相关。
Fertility induction associated with improved peripheral reproductive parameters in male mice subjected to GH and levothyroxine replacement.
作者信息
Azevedo Bruna Viscardi, Marques Juliana Moreira, Trigueiro Nicholas, Yariwake Victor Yuji, Veras Mariana Matera, Tamashiro Leticia Kaory, Cruz Robison, de Carvalho Luciani R Silveira
机构信息
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo Laboratório de Hormônios e Genética Molecular LIM/42 Divisão de Endocrinologia São PauloSP Brasil Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Laboratório de Hormônios e Genética Molecular LIM/42 - Divisão de Endocrinologia, São Paulo, SP, Brasil.
Faculdade de Medicina da Universidade de São Paulo Departamento de Patologia Hospital das Clínicas São PauloSP Brasil Hospital das Clínicas, Laboratório de Poluição Atmosférica Experimental LIM/6 - Departamento de Patologia da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil.
出版信息
Arch Endocrinol Metab. 2024 Nov 6;68(Spec Issue):e240086. doi: 10.20945/2359-4292-2024-0086. eCollection 2024.
OBJECTIVE
The aim of this study was to characterize the parameters of reproductive anatomy and pituitary hormone expression levels in ames dwarf mice ).
MATERIALS AND METHODS
Male mice aged 30 days received daily intraperitoneal injections of recombinant human GH and levothyroxine three times weekly for 60 days. The sexual maturation of these animals was compared with that of their wild-type ( ) and untreated ( ) siblings.
RESULTS
The treated group developed sexual maturation 2 weeks later than the group and presented an increase in testicular weight, complete spermatogenesis, and enhanced LH and FSH expression. The untreated group had low FSH expression and no offspring; most animals in this group did not develop sexual maturation during the study period.
CONCLUSION
Replacement with GH and levothyroxine appeared to play a crucial role in restoring peripheral reproductive parameters and increasing pituitary hormone expression in mice.
目的
本研究旨在描述艾姆斯侏儒小鼠的生殖解剖参数和垂体激素表达水平。
材料与方法
30日龄雄性小鼠每周三次腹腔注射重组人生长激素和左甲状腺素，持续60天。将这些动物的性成熟情况与其野生型和未处理的同窝小鼠进行比较。
结果
治疗组比野生型组性成熟延迟2周，睾丸重量增加，精子发生完全，促黄体生成素（LH）和促卵泡生成素（FSH）表达增强。未处理组FSH表达低且无后代；该组大多数动物在研究期间未出现性成熟。
结论
生长激素和左甲状腺素替代似乎在恢复艾姆斯侏儒小鼠外周生殖参数和增加垂体激素表达方面起着关键作用。
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