Moos Łukasz, Chodak Weronika, Czyczerska Magdalena, Garbino Karolina, Gleba Oktawia, Śnietka Bartosz, Brzoza Zenon
Department of Internal Medicine, Allergology, Endocrinology and Gastroenterology, University Hospital, Opole, Poland.
Students Scientific Association "Alergos", Faculty of Medicine, University of Opole, Department of Internal Medicine, Allergology, Endocrinology and Gastroenterology, University Hospital, Opole, Poland.
Postepy Dermatol Alergol. 2024 Dec;41(6):617-621. doi: 10.5114/ada.2024.143640. Epub 2024 Sep 30.
Chronic spontaneous urticaria (CSU) is defined as the appearance of itchy wheals and/or angioedema for at least 6 weeks. Cigarette smoking is one of the world's most common addictions. It is a cause of serious diseases such as renal cancer or thromboembolic incidents. Nevertheless, some studies show that nicotine might have a protective effect on various autoimmune diseases. The neutrophil-lymphocyte ratio (NLR) is a good marker of inflammation.
To check the prevalence of smokers in our CSU patients and to assess their profile of NLR as a marker of inflammation.
68 adult patients were included (52 females, and 16 males). The average age of respondents was 52. All of the patients were diagnosed with CSU. The group was divided by gender and smoking. The Mann-Whitney U test (Statistica ver.13) was used.
73.5% of the respondents were non-smokers, and the remaining 26.5% were smokers. In the female group, irrespective of smoking, statistically significant different levels of neutrophils (NEU), lymphocytes (LYM), and neutrophil-lymphocyte ratio (NLR) were found compared to males. No statistical difference was found between smokers and non-smokers regarding the level of inflammatory factors. Compared to males, females had significantly different levels of LYM in the group of non-smokers and NEU in the group of smokers.
Our study does not support claims that smoking has a protective effect on CSU. Significant differences in NEU, LYM, and NLR need to be further investigated.
慢性自发性荨麻疹（CSU）的定义为出现瘙痒性风团和/或血管性水肿至少6周。吸烟是世界上最常见的成瘾行为之一。它是肾癌或血栓栓塞事件等严重疾病的病因。然而，一些研究表明尼古丁可能对各种自身免疫性疾病具有保护作用。中性粒细胞与淋巴细胞比值（NLR）是炎症的良好标志物。
检查我们的CSU患者中吸烟者的患病率，并评估他们作为炎症标志物的NLR情况。
纳入68例成年患者（52例女性和16例男性）。受访者的平均年龄为52岁。所有患者均被诊断为CSU。该组按性别和吸烟情况进行划分。使用曼-惠特尼U检验（Statistica ver.13）。
73.5%的受访者为非吸烟者，其余26.5%为吸烟者。在女性组中，无论吸烟与否，与男性相比，中性粒细胞（NEU）、淋巴细胞（LYM）和中性粒细胞与淋巴细胞比值（NLR）的水平在统计学上有显著差异。吸烟者和非吸烟者在炎症因子水平方面未发现统计学差异。与男性相比，女性在非吸烟者组中的LYM水平以及吸烟者组中的NEU水平有显著差异。
我们的研究不支持吸烟对CSU有保护作用的说法。NEU、LYM和NLR的显著差异需要进一步研究。
