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铁死亡及其与癌症的关系。

Ferroptosis and its relationship with cancer.

作者信息

Su Chuanchao, Xue Yiwen, Fan Siyu, Sun Xin, Si Qian, Gu Zhen, Wang Jingfei, Deng Runzhi

机构信息

Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.

出版信息

Front Cell Dev Biol. 2025 Jan 14;12:1423869. doi: 10.3389/fcell.2024.1423869. eCollection 2024.

DOI:10.3389/fcell.2024.1423869
PMID:39877159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11772186/
Abstract

Marked by iron buildup and lipid peroxidation, ferroptosis is a relatively new regulatory cell death (RCD) pathway. Many diseases like cancer, myocardial ischemia-reperfusion injury (MIRI), neurological disorders and acute renal failure (AKI) are corelated with ferroptosis. The main molecular processes of ferroptosis discovered yet will be presented here, along with the approaches in which it interacts with tumour-associated signaling pathways and its uses in systemic therapy, radiation therapy, and immunotherapy managing tumors.

摘要

铁死亡以铁蓄积和脂质过氧化为特征，是一种相对较新的调节性细胞死亡（RCD）途径。许多疾病，如癌症、心肌缺血再灌注损伤（MIRI）、神经疾病和急性肾衰竭（AKI）都与铁死亡相关。本文将介绍已发现的铁死亡的主要分子过程，以及它与肿瘤相关信号通路相互作用的方式及其在肿瘤的全身治疗、放射治疗和免疫治疗中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/bdc43f546d1c/fcell-12-1423869-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/5757a71c9812/fcell-12-1423869-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/858e7c1fbcac/fcell-12-1423869-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/6af5450e4bc8/fcell-12-1423869-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/82e0b07a9bba/fcell-12-1423869-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/cebc8df38bb7/fcell-12-1423869-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/06bc5a0cd140/fcell-12-1423869-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/792fdd56942d/fcell-12-1423869-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/bdc43f546d1c/fcell-12-1423869-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/5757a71c9812/fcell-12-1423869-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/858e7c1fbcac/fcell-12-1423869-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/6af5450e4bc8/fcell-12-1423869-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/82e0b07a9bba/fcell-12-1423869-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/cebc8df38bb7/fcell-12-1423869-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/06bc5a0cd140/fcell-12-1423869-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/792fdd56942d/fcell-12-1423869-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18ff/11772186/bdc43f546d1c/fcell-12-1423869-g008.jpg

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本文引用的文献

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c-Myc protects hepatocellular carcinoma cell from ferroptosis induced by glutamine deprivation via upregulating GOT1 and Nrf2.c-Myc 通过上调 GOT1 和 Nrf2 保护肝癌细胞免受谷氨酰胺剥夺诱导的铁死亡。
Mol Biol Rep. 2023 Aug;50(8):6627-6641. doi: 10.1007/s11033-023-08495-1. Epub 2023 Jun 26.
2
Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones.铁死亡监测不依赖于 GPX4 且受性激素差异调控。
Cell. 2023 Jun 22;186(13):2748-2764.e22. doi: 10.1016/j.cell.2023.05.003. Epub 2023 Jun 1.
3
Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Cardiomyocyte Ferroptosis.
Alox15/15-HpETE 通过促进心肌细胞铁死亡加重心肌缺血再灌注损伤。
Circulation. 2023 May 9;147(19):1444-1460. doi: 10.1161/CIRCULATIONAHA.122.060257. Epub 2023 Mar 29.
4
C-MYC Inhibited Ferroptosis and Promoted Immune Evasion in Ovarian Cancer Cells through NCOA4 Mediated Ferritin Autophagy.C-MYC 通过 NCOA4 介导的铁蛋白自噬抑制卵巢癌细胞中的铁死亡并促进免疫逃逸。
Cells. 2022 Dec 19;11(24):4127. doi: 10.3390/cells11244127.
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Alterperylenol as a Novel Thioredoxin Reductase Inhibitor Induces Liver Cancer Cell Apoptosis and Ferroptosis.交替苯并菲作为一种新型硫氧还蛋白还原酶抑制剂诱导肝癌细胞凋亡和铁死亡。
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