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视网膜退行性疾病光感受器替代疗法的进展。

Progress in photoreceptor replacement therapy for retinal degenerative diseases.

作者信息

Du Yuxin, Shen Yin

机构信息

Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China.

Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan 430071, Hubei, China.

出版信息

Cell Insight. 2024 Nov 28;4(1):100223. doi: 10.1016/j.cellin.2024.100223. eCollection 2025 Feb.

Abstract

Retinal degenerative diseases encompass a diverse range of eye conditions that result in blindness, many due to photoreceptor dysfunction and loss. Regrettably, current clinical treatments are frequently not overly effective. However, photoreceptor transplantation shows promise as a potential therapy for late-stage retinal degenerative diseases. This article will review the various donor cell sources for this transplantation, as well as the mechanisms and factors that impact donor cell integration and material transfer, donor cell maturation, and other auxiliary methods that can be combined with photoreceptor transplantation to treat these degenerative retinal diseases.

摘要

视网膜退行性疾病包括多种导致失明的眼部疾病,其中许多是由于光感受器功能障碍和丧失所致。遗憾的是,目前的临床治疗往往效果不佳。然而,光感受器移植作为晚期视网膜退行性疾病的一种潜在治疗方法显示出了前景。本文将综述这种移植的各种供体细胞来源,以及影响供体细胞整合和物质转移、供体细胞成熟的机制和因素,以及可与光感受器移植相结合来治疗这些视网膜退行性疾病的其他辅助方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9fb/11773227/0330b57f86d4/gr1.jpg

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