Koletzko B, Bretschneider A, Bremer H J
Eur J Pediatr. 1985 Mar;143(4):310-4. doi: 10.1007/BF00442310.
The fatty acid composition of different plasma lipid fractions has been estimated in a 6-month-old girl with acrodermatitis enteropathica before and after zinc supplementation. Linoleic acid and its metabolites were extremely reduced in triglycerides and sterol-esters. In contrast, n-3-fatty acids were increased in sterol-esters and phospholipids. Zinc supplementation led to quick clinical improvement, and linoleic and arachidonic acid increased rapidly in triglycerides and sterol-esters to the values of healthy infants. Fatty acids of phospholipids remained relatively stable. Our findings could be explained by impaired enteral absorption of linoleic acid. Further attention should be directed to the supply and metabolism of essential fatty acids in acrodermatitis enteropathica.
对一名患有肠病性肢端皮炎的6个月大女孩在补锌前后不同血浆脂质组分的脂肪酸组成进行了评估。亚油酸及其代谢产物在甘油三酯和甾醇酯中极度减少。相比之下，n-3脂肪酸在甾醇酯和磷脂中增加。补锌导致临床症状迅速改善，甘油三酯和甾醇酯中的亚油酸和花生四烯酸迅速增加至健康婴儿的水平。磷脂的脂肪酸保持相对稳定。我们的发现可以用亚油酸肠道吸收受损来解释。对于肠病性肢端皮炎中必需脂肪酸的供应和代谢应给予进一步关注。
