Boberg M, Croon L B, Gustafsson I B, Vessby B
Clin Sci (Lond). 1985 May;68(5):581-7. doi: 10.1042/cs0680581.
The fatty acid composition in platelet phospholipids and in the plasma lipid esters as well as the serum lipoprotein lipid concentrations were determined in 67 healthy male subjects in order to establish the relationships between blood lipids and platelets. A positive correlation was found between the concentrations of the triglyceride rich serum lipoprotein lipids and the relative percentage of saturated and monounsaturated fatty acids in plasma. The correlations were also positive between the serum high density lipoprotein-cholesterol concentration and the relative content of linoleic acid in the plasma cholesterol esters and phospholipids. Negative correlations were found between the relative percentage of saturated and monounsaturated fatty acids in the plasma lipid esters versus linoleic acid in plasma and in the platelets. On the other hand there were positive correlations between linoleic acid in the plasma lipid esters and in the platelet phospholipids. These results indicate a direct dietary influence on the platelet phospholipid fatty acid composition. The correlations between the fatty acids of the n-6 series within plasma and platelets as well as between plasma and platelets indicate that a high linoleic acid content is not associated with an increased arachidonic acid concentration. The results also indicate that the limiting metabolic step in the conversion of linoleic acid into arachidonic acid may be located at different levels in plasma and in the platelets.
测定了67名健康男性受试者血小板磷脂、血浆脂质酯中的脂肪酸组成以及血清脂蛋白脂质浓度，以建立血脂与血小板之间的关系。富含甘油三酯的血清脂蛋白脂质浓度与血浆中饱和脂肪酸和单不饱和脂肪酸的相对百分比之间呈正相关。血清高密度脂蛋白胆固醇浓度与血浆胆固醇酯和磷脂中亚油酸的相对含量之间也呈正相关。血浆脂质酯中饱和脂肪酸和单不饱和脂肪酸的相对百分比与血浆和血小板中的亚油酸之间呈负相关。另一方面，血浆脂质酯中的亚油酸与血小板磷脂中的亚油酸之间呈正相关。这些结果表明饮食对血小板磷脂脂肪酸组成有直接影响。血浆和血小板中n-6系列脂肪酸之间以及血浆与血小板之间的相关性表明，高亚油酸含量与花生四烯酸浓度升高无关。结果还表明，亚油酸转化为花生四烯酸的限速代谢步骤可能位于血浆和血小板的不同水平。
