Yilmaz Mustafa, Uslu Muhammad Fuad, Atescelık Metin, Atilgan Fethi Ahmet
Department of Emergency Medicine, Firat University, Elazig, Turkey.
Department of İnternal Medicine, Elazig Fethi Sekin City Hospital, Elazig, Turkey.
Malawi Med J. 2025 Jan 13;36(4):255-259. doi: 10.4314/mmj.v36i4.4. eCollection 2025 Jan.
The aim of this study was to examine the levels of hematologic parameters in acute ischemic stroke (AIS) and transient ischemic attack (TIA) and to evaluate the use of Neutrophil/Lymphocyte ratio (NLR), Systemic Immune-Inflammation Index (SII), and systemic inflammation response index (SIRI) in the differentiation of AIS and TIA.
Data and hematological results of patients admitted to the emergency department and diagnosed with AIS and TIA were compared retrospectively.
The study included 36 TIA patients (M/F = 15/21) with a mean age of 64.52 ± 15.597 years and 74 AIS patients (M/F = 35/39) with a mean age of 71.91 ± 13.86 years. Laboratory data showed that lymphocyte count (p = 0.022) and hemoglobin level (p = 0.017) were significantly higher in AIS patients. In addition, monocyte count (p = 0.001), neutrophil/lymphocyte ratio (NLR) (p < 0.001), CRP level (p = 0.007), and SII (p = 0.001) and SIRI values (< 0.001) were significantly increased in AIS patients compared to TIA patients.
The results obtained in the present study show that hematologic inflammatory parameters are increased in AIS. NLR, SII and SIRI may provide insight in the differential diagnosis of AIS and TIA.
本研究旨在检测急性缺血性卒中（AIS）和短暂性脑缺血发作（TIA）患者的血液学参数水平，并评估中性粒细胞/淋巴细胞比值（NLR）、全身免疫炎症指数（SII）和全身炎症反应指数（SIRI）在AIS和TIA鉴别诊断中的应用价值。
回顾性比较急诊科收治并诊断为AIS和TIA患者的数据及血液学检查结果。
本研究纳入36例TIA患者（男/女=15/21），平均年龄64.52±15.597岁，74例AIS患者（男/女=35/39），平均年龄71.91±13.86岁。实验室数据显示，AIS患者的淋巴细胞计数（p=0.022）和血红蛋白水平（p=0.017）显著更高。此外，与TIA患者相比，AIS患者的单核细胞计数（p=0.001）、中性粒细胞/淋巴细胞比值（NLR）（p<0.001）、CRP水平（p=0.007）、SII（p=0.001）和SIRI值（p<0.001）显著升高。
本研究结果表明，AIS患者的血液学炎症参数升高。NLR、SII和SIRI可能有助于AIS和TIA的鉴别诊断。
